ArticleChemical science2022
Key difference between transition state stabilization and ground state destabilization: increasing atomic charge densities before or during enzyme-substrate binding.
Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
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- Photoelectrocatalytic urea synthesis: Surface engineering of the constructions, mechanism insights, and technological challenges.iScience · 2026Review
- Catalytic Promiscuity and Cascade Reaction Mechanism of Ketosteroid Isomerases for Addition Reactions of Cyclic Enones.Nature communications · 2026Article
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- Synthetic Biology Approaches to Enzymology in Food and Agriculture Systems.Journal of agricultural and food chemistry · 2026Review
- An experimental investigation of vibrational, optical, and dielectric properties of Li-Mg ferrite for potential high-frequency and optoelectronic applications.RSC advances · 2025Article
- Systematic pore lipophilization to enhance the efficiency of an amine-based MOF catalyst in the solvent-free Knoevenagel reaction.Beilstein journal of organic chemistry · 2025Article
- Article
- Enhanced surface functionalization of 2D molybdenum/tin chalcogenide nanostructures for effective SERS detection ofRSC advances · 2024Article
- Synergistic charge-transfer dynamics of novel D-D-A-π-A framework containing indoline-benzo[d][1,2,3]thiadiazole based push-pull sensitizers: from structural engineering to performance metrics in photovoltaic solar cells.Journal of molecular modeling · 2024Article
- AFORS-HET-based numerical exploration of tunnel oxide passivated contact solar cells incorporating n- and p-type silicon substrates.RSC advances · 2024Article
- Study of half-metallic ferromagnetism and transport characteristics of double perovskites SrRSC advances · 2024Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The origin of the enormous catalytic power of enzymes has been extensively studied through experimental and computational approaches. Although precise mechanisms are still subject to much debate, enzymes are thought to catalyze reactions by stabilizing transition states (TSs) or destabilizing ground states (GSs). By exploring the catalysis of various types of enzyme-substrate noncovalent interactions, we found that catalysis by TS stabilization and the catalysis by GS destabilization share common features by reducing the free energy barriers (Δ
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.