ArticleEuropean heart journal open2022
Five-year clinical outcomes in patients with frailty aged ≥75 years with non-ST elevation acute coronary syndrome undergoing invasive management.
Article in European heart journal open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01933581 (ICON1), which is not on this map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ICON1: A Study to Improve Cardiovascular Outcomes in High Risk PatieNts With Acute Coronary Syndrome
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Impact of frailty on post-procedural adverse outcomes in older adults aged ≥75 years undergoing percutaneous coronary intervention: a systematic review of observational studies.Frontiers in medicine · 2026Pooled it
- Invasive Versus Conservative Management Among Older Adult Patients With Non-ST-Segment-Elevation Myocardial Infarction: A Meta-Analysis of Randomized Controlled Trials.Journal of the American Heart Association · 2025Pooled it
- Invasive Strategy With Intended Percutaneous Coronary Intervention Versus Conservative Treatment in Older People With ST-Segment-Elevation Myocardial Infarction: A Meta-Analysis.Journal of the American Heart Association · 2025Pooled it
- Invasive vs. conservative management of older patients with non-ST-elevation acute coronary syndrome: individual patient data meta-analysis.European heart journal · 2024Pooled it
- Invasive vs Conservative Strategy for Frail Older Patients With Myocardial Infarction: A Secondary Analysis of the SENIOR-RITA Randomized Clinical Trial.JAMA network open · 2026Trial
- Ischemic Evaluation and Long-Term Mortality in New-Onset Heart Failure Across Various Age-Groups.International journal of heart failure · 2026Article
- Frailty scale with the best prediction of mortality in individuals diagnosed with acute coronary syndrome: systematic review and meta-analysis.Journal of geriatric cardiology : JGC · 2026Article
- The role of frailty in older adults with Non-ST-elevation acute coronary syndrome: a Chinese population-based cohort study.Aging clinical and experimental research · 2025Article
- Associations of life's crucial 9 with mortality among older adults with frailty: a prospective cohort study from the NHANES 2007 to 2018.BMC geriatrics · 2025Article
- Older women with non-ST-elevation acute coronary syndrome undergoing invasive or conservative management: an individual patient data meta-analysis.European heart journal open · 2024Article
- Current Management of Non-ST-Segment Elevation Acute Coronary Syndrome.Biomedicines · 2024Review
- Prevalence of frailty and association with patient centered outcomes: A prospective registry-embedded cohort study from India.Journal of critical care · 2024Article
- Article
- Pre-existing frailty in the elderly and long-term mortality following percutaneous coronary intervention.Journal of geriatric cardiology : JGC · 2023Article
- Management of Acute Coronary Syndrome in the Older Adult Population: A Scientific Statement From the American Heart Association.Circulation · 2023Review
- Effect of Frailty on the Long-Term Prognosis of Elderly Patients with Acute Myocardial Infarction.Clinical interventions in aging · 2023Article
- Beyond MACE: a multidimensional approach to outcomes in clinical trials for older adults with stable ischemic heart disease.Frontiers in cardiovascular medicine · 2023Review
- Angiographic and Procedural Characteristics in Frail Older Patients with Non-ST Elevation Acute Coronary Syndrome.Interventional cardiology (London, England) · 2023Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: Frailty is associated with adverse outcomes in older patients with acute coronary syndrome (ACS). The impact of frailty on long-term clinical outcomes following invasive management of non-ST elevation ACS (NSTEACS) is unknown. Methods and results: The multi-centre Improve Clinical Outcomes in high-risk patieNts with ACS 1 (ICON-1) prospective cohort study consisted of patients aged >75 years undergoing coronary angiography following NSTEACS. Patients were categorized by frailty assessed by Canadian Study of Health and Ageing Clinical Frailty Scale (CFS) and Fried criteria. The primary composite endpoint was all-cause mortality, unplanned revascularization, myocardial infarction, stroke, and bleeding. Of 263 patients, 33 (12.5%) were frail, 152 (57.8%) were pre-frail, and 78 (29.7%) were robust according to CFS. By Fried criteria, 70 patients (26.6%, mean age 82.1 years) were frail, 147 (55.9%, mean age 81.3 years) were pre-frail, and 46 (17.5%, mean age 79.9 years) were robust. The composite endpoint was more common at 5 years among patients with frailty according to CFS (frail: 22, 66.7%; pre-frail: 81, 53.3%; robust: 27, 34.6%, Conclusion: In older patients who underwent angiography following NSTEACS, frailty is associated with an increased risk of the primary composite endpoint at 5 years. Registration: Clinicaltrials.gov NCT01933581.
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