Evidence map›Paper›PMID 35919344›Full record

ArticleEuropean heart journal open2022

Paradoxical prolongation of QT interval during exercise in patients with hypertrophic cardiomyopathy: cellular mechanisms and implications for diastolic function.

Raffaele Coppini, Matteo Beltrami, Ruben Doste, Alfonso Bueno-Orovio, Cecilia Ferrantini, Giulia Vitale, Josè Manuel Pioner, Lorenzo Santini, Alessia Argirò, Martina Berteotti and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Atrial electrophysiology in hypertrophic cardiomyopathy: current insights and knowledge gaps.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Raffaele CoppiniDepartment NeuroFarBa, University of Florence, Viale G. Pieraccini 6, 50139 Florence, Italy.ORCID https://orcid.org/0000-0002-4096-3173
Matteo BeltramiCardiomyopathy Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Firenze, Italy.ORCID https://orcid.org/0000-0001-7161-3224
Ruben DosteDepartment of Computer Science, University of Oxford, Wolfson Building, Parks Rd, Oxford OX1 3QD, UK.ORCID https://orcid.org/0000-0003-4187-4970
Alfonso Bueno-OrovioDepartment of Computer Science, University of Oxford, Wolfson Building, Parks Rd, Oxford OX1 3QD, UK.ORCID https://orcid.org/0000-0002-1634-3601
Cecilia FerrantiniDepartment of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134 Firenze, Italy.
Giulia VitaleDepartment of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134 Firenze, Italy.
Josè Manuel PionerDepartment of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134 Firenze, Italy.ORCID https://orcid.org/0000-0003-0179-3033
Lorenzo SantiniDepartment NeuroFarBa, University of Florence, Viale G. Pieraccini 6, 50139 Florence, Italy.
Alessia ArgiròCardiomyopathy Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Firenze, Italy.ORCID https://orcid.org/0000-0002-6394-9948
Martina BerteottiCardiomyopathy Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Firenze, Italy.
Fabio MoriCardiothoracovascular Department, Careggi University Hospital, Largo Brambilla 3, 50134 Firenze, Italy.
Niccolò MarchionniDepartment of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134 Firenze, Italy.
Pierluigi StefànoDepartment of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134 Firenze, Italy.ORCID https://orcid.org/0000-0001-8338-3016
Elisabetta CerbaiDepartment NeuroFarBa, University of Florence, Viale G. Pieraccini 6, 50139 Florence, Italy.ORCID https://orcid.org/0000-0001-7839-1361
Corrado PoggesiDepartment of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134 Firenze, Italy.ORCID https://orcid.org/0000-0003-2624-4778
Iacopo OlivottoCardiomyopathy Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Firenze, Italy.
Azienda Ospedaliero-Universitaria Careggi · ITUniversity of Florence · ITUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Ventricular cardiomyocytes from hypertrophic cardiomyopathy (HCM) patient hearts show prolonged action potential duration (APD), impaired intracellular Ca Methods and results: Non-obstructive HCM patients (178) and control subjects (81) underwent standard exercise testing, including exercise echocardiography. Ventricular myocytes were isolated from myocardial samples of 23 HCM and eight non-failing non-hypertrophic surgical patients. The APD shortening in response to high frequencies was maintained in HCM myocytes, while β-adrenergic stimulation unexpectedly prolonged APDs, ultimately leading to a lesser shortening of APDs in response to exercise. In HCM vs. control subjects, we observed a lesser shortening of QT interval at peak exercise (QTc: +27 ± 52 ms in HCM, -4 ± 50 ms in controls, Conclusions: Abnormal balance of Ca

Indexed as

Action potentialBeta adrenergic receptorCardiac relaxationCardiomyocytesRepolarizationStress echocardiography

Identifiers

PMID35919344
PMCPMC9242073
OpenAlexW4280598294

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.