Evidence map›Paper›PMID 35919341›Full record

ArticleEuropean heart journal open2022

Comorbidities may offset expected improved survival after transcatheter aortic valve replacement.

Pierre Lantelme, Matthieu Aubry, Jacques Chan Peng, Benjamin Riche, Géraud Souteyrand, Philippe Jaafar, Muriel Rabilloud, Brahim Harbaoui, Olivier Muller, Benoit Cosset and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Pierre LantelmeService de Cardiologie, Hôpital de la Croix-Rousse et Hôpital Lyon Sud, Hospices Civils de Lyon, 103 Grande Rue de la Croix-Rousse, 69004 Lyon, France.ORCID https://orcid.org/0000-0001-5259-1613
Matthieu AubryService de Cardiologie, Hôpital de la Croix-Rousse et Hôpital Lyon Sud, Hospices Civils de Lyon, 103 Grande Rue de la Croix-Rousse, 69004 Lyon, France.ORCID https://orcid.org/0000-0002-8708-8468
Jacques Chan PengDépartement de cardiologie, Centre Hospitalo-Universitaire de Nantes, Nantes, France.
Benjamin RicheCentre National de la Recherche Scientifique, UMR 5558, Laboratoire de Biométrie et Biologie Évolutive, Équipe Biostatistique-Santé, Université Lyon 1, Villeurbanne, France.
Géraud SouteyrandDépartement de cardiologie, Centre Hospitalo-Universitaire Gabriel Montpied, Image Science for Interventional Techniques, Cardiovascular Interventional Therapy and Imaging, Centre National de la Recherche Scientifique UMR 6284, Université d'Auvergne, Clermont-Ferrand, France.
Philippe JaafarDépartement de cardiologie, Centre Hospitalo-Universitaire de Nantes, Nantes, France.
Muriel RabilloudCentre National de la Recherche Scientifique, UMR 5558, Laboratoire de Biométrie et Biologie Évolutive, Équipe Biostatistique-Santé, Université Lyon 1, Villeurbanne, France.
Brahim HarbaouiService de Cardiologie, Hôpital de la Croix-Rousse et Hôpital Lyon Sud, Hospices Civils de Lyon, 103 Grande Rue de la Croix-Rousse, 69004 Lyon, France.ORCID https://orcid.org/0000-0003-0400-6234
Olivier MullerDépartement de cardiologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.ORCID https://orcid.org/0000-0003-2441-5799
Benoit CossetDepartment of Cardiac Surgery, Hôpital Louis Pradel, Hospices Civils de Lyon, Lyon, France.
Mattia PagnoniDépartement de cardiologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Thibaut ManigoldDépartement de cardiologie, Centre Hospitalo-Universitaire de Nantes, Nantes, France.
Université Claude Bernard Lyon 1 · FRCentre Hospitalier Universitaire de Nantes · FRUniversity Hospital of Lausanne · CHHospices Civils de Lyon · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: After transcatheter aortic valve replacement (TAVR), cardiovascular and non-cardiovascular comorbidities may offset the survival benefit from the procedure. We aimed to describe the relationships between that benefit and patient comorbidities. Methods and results: The study pooled two European cohorts of patients with severe aortic stenosis (AS-pooled): one with patients who underwent (cohort of AS patients treated by TAVR, Conclusion: The study showed that, beyond a given comorbidity burden (as assessed by CAPRI and Charlson scores), the probability of death within a year was high and poorly reduced by TAVR. This indicates the futility of TAVR in patients in the poor prognosis category.

Indexed as

ComorbiditiesMedical futilityMortalityOrgan dysfunction scoresTranscatheter aortic valve replacement

Identifiers

PMID35919341
PMCPMC9242031
OpenAlexW4224096332

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.