ArticleInternational journal of ophthalmology2022
Temporal retinal thinning might be an early diagnostic indicator in male pediatric X-linked Alport syndrome.
Article in International journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 3 citations in OpenAlex.
- Diagnostic value of OCT-based temporal macular retinal thinning in children with hereditary glomerular diseases.International journal of ophthalmology · 2026Article
- Characterization of Ocular Morphology in Col4a3-/- Mice as a Murine Model for Alport Syndrome.Translational vision science & technology · 2024Article
- Case report: Surgical and clinical results in bilateral lenticonus due to Alport syndrome.Romanian journal of ophthalmologyArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
aimTo evaluate temporal retinal thinning changes in retinal layers using spectral-domain optical coherence tomography (SD-OCT) in pediatric X-linked Alport syndrome (XLAS) patients.
methodsA retrospective case-control study. SD-OCT scans of pediatric patients diagnosed with XLAS and age- and sex-matched healthy control participants were reviewed. Automated segmentation of SD-OCT scans was induced to analyze the retinal thickness (RT) of different layers. The temporal thinning index (TTI) was calculated for each layer and compared between the patients and the control group.
resultsForty-three pediatric XLAS patients and 60 healthy controls were included. Temporal retinal thinning was present in 33 patients (76.74%), while 28 patients (65.11%) had severe pathological temporal retinal thinning and 5 patients (11.63%) had moderate thinning. The temporal inner sector RT (
conclusionTemporal retinal thinning appears early in XLAS patients, especially in male patients. The thinning is mainly caused by structural abnormalities of the inner retina. This suggests that temporal retinal thinning could be helpful for the early diagnosis and follow-up of XLAS with noninvasive SD-OCT examination.
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