Evidence map›Paper›PMID 35919224›Full record

ArticleEcancermedicalscience2022

Evaluation of total oxidative stress and antioxidant capacity of brain tumour patients attending referral hospitals in Addis Ababa, 2020: a comparative cross-sectional study.

Fitalew Tadele Admasu, Biruk Demissie, Getachew Yideg Yitbarek, Zeleke Geto, Aragaw Tesfaw, Edget Abebe Zewde, Animut Tilahun, Gashaw Walle, Tigist Tefera Bekele, Mezgebu Legesse Habte and 9 more

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In one paragraph

Article in Ecancermedicalscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Fitalew Tadele AdmasuDepartment of Biomedical Science, School of Medicine, College of Health Sciences, Debre Tabor University, Debre Tabor, 272, Ethiopia.
Biruk DemissieDepartment of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, 272, Ethiopia.
Getachew Yideg YitbarekDepartment of Biomedical Science, School of Medicine, College of Health Sciences, Debre Tabor University, Debre Tabor, 272, Ethiopia.
Zeleke GetoDepartment of Biomedical Sciences, School of Medicine, College of Health Sciences, Wello University, Wello, 1242, Ethiopia.
Aragaw TesfawDepartment of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, 272, Ethiopia.
Edget Abebe ZewdeDepartment of Biomedical Science, School of Medicine, College of Health Sciences, Debre Tabor University, Debre Tabor, 272, Ethiopia.
Animut TilahunDepartment of Biomedical Science, School of Medicine, College of Health Sciences, Debre Tabor University, Debre Tabor, 272, Ethiopia.
Gashaw WalleDepartment of Biomedical Science, School of Medicine, College of Health Sciences, Debre Tabor University, Debre Tabor, 272, Ethiopia.
Tigist Tefera BekeleDepartment of Biochemistry, College of Biomedical Sciences, School of Medicine, College of Health Sciences and Medicine, Haramaya University, Harer, 138, Ethiopia.
Mezgebu Legesse HabteDepartment of Biochemistry, College of Biomedical Sciences, School of Medicine, College of Health Sciences and Medicine, Haramaya University, Harer, 138, Ethiopia.
Teka Obsa FeyisaDepartment of Biochemistry, College of Biomedical Sciences, School of Medicine, College of Health Sciences and Medicine, Haramaya University, Harer, 138, Ethiopia.
Tadeg Jemere AmareDepartment of Biomedical Science, School of Medicine, College of Health Sciences, Debre Tabor University, Debre Tabor, 272, Ethiopia.
Wubet AlebachewDepartment of Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, 272, Ethiopia.
Sintayehu AsnakewDepartment of Psychiatry, School of Medicine, College of Health Sciences, Debre Tabor University, Debre Tabor, 272, Ethiopia.
Ermiyas SisayDepartment of Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, 272, Ethiopia.
Markeshaw TirunehDepartment of Biochemistry, School of Medicine, College of Health Sciences and medicine, Gondar University, Gondar, 196, Ethiopia.
Getaneh Atikilt YemataDepartment of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, 272, Ethiopia.
Tigabu Munye AytenewDepartment of Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, 272, Ethiopia.
Tadesse Asmamaw DejenieDepartment of Biochemistry, School of Medicine, College of Health Sciences and medicine, Gondar University, Gondar, 196, Ethiopia.
Debre Tabor University · ETHaramaya University · ETUniversity of Gondar · ETWollo University · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The exact cause of brain tumours is still unknown, but disruptions of redox balance are thought to play a significant role in all stages of brain tumour development. However, the roles of free radical imbalance at different grades of brain tumour and degree of oxidative stress before and after surgery have not been addressed in prior studies. Aim: A comparative cross-sectional study was conducted to assess the redox imbalance among confirmed brain tumour patients. Methods and results: An institution-based comparative cross-sectional study was conducted on a total of 100 participants (50 brain tumour patients and 50 controls) at referral hospitals in Addis Ababa, Ethiopia. Descriptive statistics, Conclusion: Higher oxidant and lower antioxidant levels were found in the serum of brain tumour patients than in the control group. The post-surgery oxidant level was lower than the pre-surgery state. The findings of this study could suggest that redox imbalance may have a role in the pathophysiology of brain tumours, but further experimental studies are needed.

Indexed as

brain tumourEthiopiaoxidative stresstumour gradetumour metabolism

Identifiers

PMID35919224
PMCPMC9300404
OpenAlexW4280504704

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.