Evidence map›Paper›PMID 35919168›Full record

ReviewRSC advances2022

Beyond GalNAc! Drug delivery systems comprising complex oligosaccharides for targeted use of nucleic acid therapeutics.

Joseph O'Sullivan, Jose Muñoz-Muñoz, Graeme Turnbull, Neil Sim, Stuart Penny, Sterghios Moschos

Open access · goldAbstract readReview
In one paragraph

Review in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Target, silence, replace: a review on RNA-based drugs in modern medicine.Frontiers in cell and developmental biology · 2026
    Review
  4. Review
  5. Review
  6. Messenger RNA-Based Therapeutics and Vaccines: What's beyond COVID-19?ACS pharmacology & translational science · 2023
    Review
  7. Article
  8. A Comprehensive Review of mRNA Vaccines.International journal of molecular sciences · 2023
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Joseph O'SullivanDepartment of Applied Sciences, Northumbria University Newcastle upon Tyne UK NE1 8ST sterghios.moschos@northumbria.ac.uk.ORCID https://orcid.org/0000-0002-7977-023X
Jose Muñoz-MuñozDepartment of Applied Sciences, Northumbria University Newcastle upon Tyne UK NE1 8ST sterghios.moschos@northumbria.ac.uk.
Graeme TurnbullDepartment of Applied Sciences, Northumbria University Newcastle upon Tyne UK NE1 8ST sterghios.moschos@northumbria.ac.uk.ORCID https://orcid.org/0000-0003-2606-3387
Neil SimHigh Force Research Ltd, Bowburn North Industrial Estate Durham UK DH6 5PF.
Stuart PennyHigh Force Research Ltd, Bowburn North Industrial Estate Durham UK DH6 5PF.
Sterghios MoschosDepartment of Applied Sciences, Northumbria University Newcastle upon Tyne UK NE1 8ST sterghios.moschos@northumbria.ac.uk.ORCID https://orcid.org/0000-0001-6038-3785
Northumbria University · GBHigh Force Research (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleic Acid Therapeutics (NATs) are establishing a leading role for the management and treatment of genetic diseases following FDA approval of nusinersen, patisiran, and givosiran in the last 5 years, the breakthrough of milasen, with more approvals undoubtedly on the way. Givosiran takes advantage of the known interaction between the hepatocyte specific asialoglycoprotein receptor (ASGPR) and

Identifiers

PMID35919168
PMCPMC9281799
OpenAlexW4285413956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.