ArticleQuantitative imaging in medicine and surgery2022
Metabolite changes in prefrontal lobes and the anterior cingulate cortex correlate with processing speed and executive function in Parkinson disease patients.
Article in Quantitative imaging in medicine and surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 5 citations in OpenAlex.
- Processing speed impairment after anterior communicating artery aneurysm rupture assessed using the wechsler adult intelligence scale: an observational study.BMC neurology · 2026Observational
- Serum Creatinine Clearance and Cognitive Function in Older Adults: Mediating Effects of Systemic Inflammatory Response Index.Brain and behavior · 2026Article
- The cerebral metabolic mechanism of group computer magnanimous therapy based on magnetic resonance spectroscopy: effects on improving magnanimous-enterprising levels of lung cancer patients.Frontiers in psychiatry · 2024Article
- Comparative study of bilateral putamen for patients with severe Parkinson's disease detected byQuantitative imaging in medicine and surgery · 2023Article
- Executive Functions and Public Health: A Narrative Review.Iranian journal of public health · 2023Review
- Stroke-Related Alterations in the Brain's Functional Connectivity Response Associated with Upper Limb Multi-Joint Linkage Movement.Brain sciences · 2023Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
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Abstract
Background: Processing speed and executive function can be impaired in patients with Parkinson disease (PD). However, the neural factors related to the slowdown in processing speed and dysexecutive function in PD are not completely understood. The objective of this study is to investigate the metabolic changes of the frontal and anterior cingulate cortex (ACC) through the use of Methods: In this retrospective case-control study, we conducted neuropsychological assessments of executive function and information processing speed in healthy controls (HCs) and in patients with PD. Chemical information was obtained for the of N-acetyl-aspartate (NAA):creatine (Cr) ratio and the choline-containing compounds (Cho):Cr ratio within the bilateral prefrontal cortex and ACC. Using hierarchical multiple regression analysis, we analyzed the relationship between cognitive function and metabolic ratios in the bilateral prefrontal lobe and ACC in patients with PD. Results: In all, 59 patients with PD and 30 HCs were recruited. Patients with PD showed worse performance in executive function and processing speed compared with HCs (P<0.001). In patients with PD, the Cho:Cr ratios in the ACC (Z=2.20, P=0.028) and the right prefrontal cortex ( Conclusions: Information processing speed and executive function are impaired in patients with PD. Neuronal integrity and membrane turnover in the ACC and the right prefrontal cortex may be important factors in the slowdown of the information processing speed in patients with PD.
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