Evidence map›Paper›PMID 35918946›Full record

ArticleIndian journal of ophthalmology2022

Accelerated corneal collagen cross-linking in progressive keratoconus: Five-year results and predictors of visual and topographic outcomes.

Tommy C Y Chan, Rachel W Y Tsui, Vanissa W S Chow, Jasmine K M Lam, Victoria W Y Wong, Kelvin H Wan

Abstract read
In one paragraph

Article in Indian journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Commentary: Bunsen-Roscoe reciprocity - Is it still valid?Indian journal of ophthalmology · 2022
    Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Tommy C Y ChanDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong; Department of Ophthalmology, Hong Kong Sanatorium and Hospital, Hong Kong.
Rachel W Y TsuiDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong; Hong Kong Eye Hospital, Hong Kong.
Vanissa W S ChowDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong; Hong Kong Eye Hospital, Hong Kong.
Jasmine K M LamDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong; Hong Kong Eye Hospital, Hong Kong.
Victoria W Y WongDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong; Hong Kong Eye Hospital; LKS Faculty of Medicine, The University of Hong Kong, Hong Kong.
Kelvin H WanDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong; Hong Kong Eye Hospital, Hong Kong.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To analyze the 5-year results of accelerated corneal collagen crosslinking (CXL) for progressive keratoconus and identify preoperative characteristics predictive of visual and topographic outcomes. Methods: A prospective interventional case series. Nineteen eyes of 19 patients receiving accelerated CXL with settings of 18 mW/cm Results: Corrected distance visual acuity (CDVA) remained stable from 0.28 ± 0.21 to 0.25 ± 0.18 logMAR (P = 0.486). The mean cylindrical refraction was stable (P = 0.119). The maximal keratometry (Kmax) decreased from 61.99 ± 10.37 to 59.25 ± 7.75 D (P < 0.001), flattening in the flattest and steepest meridians and mean keratometry were also observed (P ≤ 0.040). The mean anterior elevation at the apex reduced from 21.42 ± 16.69 to 18.53 ± 12.74 μm (P = 0.013) and changes in posterior elevation were non-significant (P = 0.629). Preoperative Kmax best predicted the postoperative change in Kmax (R Conclusion: Kmax significantly decreased following accelerated CXL. Eyes with worse preoperative CDVA and higher Kmax were more likely to have an improvement in visual acuity and corneal flattening.

Indexed as

KeratoconusPhotochemotherapyCollagenCorneal TopographyCross-Linking ReagentsHumansPhotosensitizing AgentsProspective StudiesRiboflavinUltraviolet RaysCollagenCross-Linking ReagentsPhotosensitizing AgentsRiboflavinCollagen crosslinkingkeratoconuskeratometrytopography

Identifiers

PMID35918946
PMCPMC9672700

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.