Evidence map›Paper›PMID 35918888›Full record

ArticleJournal of dental research2022

TLR9 Mediates Periodontal Aging by Fostering Senescence and Inflammaging.

E Albuquerque-Souza, K E Crump, K Rattanaprukskul, Y Li, B Shelling, X Xia-Juan, M Jiang, S E Sahingur

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

E Albuquerque-SouzaDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
K E CrumpDepartment of Biological Sciences, Nova Southeastern University, Fort Lauderdale, FL, USA.
K RattanaprukskulDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Y LiDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
B ShellingDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
X Xia-JuanDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
M JiangDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
S E SahingurDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
University of Pennsylvania · USNova Southeastern University · US

Funding

Microbial Nucleic Acid Sensing in PeriodontitisR01DE025037 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI SAHINGUR, SINEM ESRA · 2015 to 2019
$1.9M
Endogenous Regulators of Inflammation in Periodontal Tissue HomeostasisR01DE027374 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI SAHINGUR, SINEM ESRA · 2018 to 2022
$1.9M
NIDCR NIH HHS R01 DE025037NIDCR NIH HHS R01 DE027374
6 · The paper itself

Abstract

TLR9 is a critical nucleic acid sensing receptor in mediating periodontitis and periodontitis-associated comorbidities. Emerging evidence implicates TLR9 as a key sensor during aging, although its participation in periodontal aging is unexplored. Here, we investigated whether TLR9-mediated host responses can promote key hallmarks of aging, inflammaging, and senescence, in the course of periodontitis using a multipronged approach comprising clinical and preclinical studies. In a case-control model, we found increased TLR9 gene expression in gingival tissues of older (≥55 y) subjects with periodontitis compared to older healthy subjects as well as those who are younger (<55 y old) with and without the disease. Mechanistically, this finding was supported by an in vivo model in which wild-type (WT) and TLR9

Indexed as

Alveolar Bone LossPeriodontitisAgingAnimalsMiceOsteoclastsToll-Like Receptor 9Tlr9 protein, mouseToll-Like Receptor 9cellular senescencemacrophagesnucleic acidsperiodontitisS100 proteinstoll-like receptor 9

Identifiers

PMID35918888
PMCPMC9703528
OpenAlexW4289521672

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.