Evidence map›Paper›PMID 35918731›Full record

ArticlePilot and feasibility studies2022

Coordination of Oral Anticoagulant Care at Hospital Discharge (COACHeD): protocol for a pilot randomised controlled trial.

Anne M Holbrook, Kristina Vidug, Lindsay Yoo, Sue Troyan, Sam Schulman, James Douketis, Lehana Thabane, Stephen Giilck, Yousery Koubaesh, Sylvia Hyland and 9 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pilot and feasibility studies, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02777047 (Coordination of Oral Anticoagulant Care at Hospital Discharge), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02777047 nacompletednot on this map

Coordination of Oral Anticoagulant Care at Hospital Discharge (COACHeD): A Pilot Randomized Trial

TypeinterventionalSponsorSt. Joseph's Healthcare HamiltonRan2020 to 2022Enrolled56ConditionsAnticoagulantsArmsAnticoagulation Coordinated Care
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 1 country.

Anne M HolbrookDivision of Clinical Pharmacology and Toxicology, Department of Medicine, McMaster University, Hamilton, ON, Canada. holbrook@mcmaster.ca.ORCID http://orcid.org/0000-0002-3371-4187
Kristina VidugClinical Pharmacology Research, Research Institute of St Joes Hamilton, Hamilton, ON, Canada.
Lindsay YooClinical Pharmacology Research, Research Institute of St Joes Hamilton, Hamilton, ON, Canada.
Sue TroyanClinical Pharmacology Research, Research Institute of St Joes Hamilton, Hamilton, ON, Canada.
Sam SchulmanDivsion of Hematology and Thromboembolism, Department of Medicine, McMaster University, Hamilton, ON, Canada.
James DouketisDepartment of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, ON, Canada.
Lehana ThabaneClinical Pharmacology Research, Research Institute of St Joes Hamilton, Hamilton, ON, Canada.
Stephen GiilckDivision of General Internal Medicine, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Yousery KoubaeshDivision of General Internal Medicine, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Sylvia HylandInstitute for Safe Medication Practices Canada, North York, ON, Canada.
Karim KeshavjeeInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.
Joanne HoDivision of Clinical Pharmacology and Toxicology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Jean-Eric TarrideDepartment of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, ON, Canada.
Amna AhmedDivision of General Internal Medicine, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Marianne TalmanDivision of General Internal Medicine, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Blair LeonardDepartment of Medicine, Niagara Health System, Regional Municipality of Niagara, Canada.
Khursheed AhmedClinical Pharmacology Research, Research Institute of St Joes Hamilton, Hamilton, ON, Canada.
Mohammad RefaeiDepartment of Medicine, Niagara Health System, Regional Municipality of Niagara, Canada.
Deborah M SiegalDivision of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada.
St. Joseph’s Healthcare Hamilton · CAHamilton Health Sciences · CAImpact · CAMcMaster University · CARegional Municipality of Niagara · CAGrand River Hospital · CAPopulation Health Research Institute · CAPrograms for Assessment of Technology in Health Research Institute · CAUniversity of Ottawa · CAUniversity of Toronto · CAUniversity of Waterloo · CA

Funding

CIHR 365834
6 · The paper itself

Abstract

backgroundOral anticoagulants (OACs) are commonly prescribed, have well-documented benefits for important clinical outcomes but have serious harms as well. Rates of OAC-related adverse events including thromboembolic and hemorrhagic events are especially high shortly after hospital discharge. Expert OAC management involving virtual care is a research priority given its potential to reach remote communities in a more feasible, timely, and less costly way than in-person care. Our objective is to test whether a focused, expert medication management intervention using a mix of in-person consultation and virtual care follow-up, is feasible and effective in preventing anticoagulation-related adverse events, for patients transitioning from hospital to home. METHODS AND ANALYSIS: A randomized, parallel, multicenter design enrolling consenting adult patients or the caregivers of cognitively impaired patients about to be discharged from medical wards with a discharge prescription for an OAC. The interdisciplinary multimodal intervention is led by a clinical pharmacologist and includes a detailed discharge medication reconciliation and management plan focused on oral anticoagulants at hospital discharge; a circle of care handover and coordination with patient, hospital team and community providers; and early post-discharge follow-up virtual medication check-up visits at 24 h, 1 week, and 1 month. The control group will receive usual care plus encouragement to use the Thrombosis Canada website. The primary feasibility outcomes include recruitment rate, participant retention rates, trial resources management, and the secondary clinical outcomes include adverse anticoagulant safety events composite (AASE), coordination and continuity of care, medication-related problems, quality of life, and healthcare resource utilization. Follow-up is 3 months. DISCUSSION: This pilot RCT tests whether there is sufficient feasibility and merit in coordinating oral anticoagulant care early post-hospital discharge to warrant a full sized RCT.

trial registrationNCT02777047.

Indexed as

AnticoagulationHospital dischargeMedication managementPilot trialTransitional care

Identifiers

PMID35918731
PMCPMC9344454
OpenAlexW4289524024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.