Evidence map›Paper›PMID 35918727›Full record

ArticleJournal of nanobiotechnology2022

Multifunctional fish gelatin hydrogel inverse opal films for wound healing.

Xinyue Cao, Zhuohao Zhang, Lingyu Sun, Zhiqiang Luo, Yuanjin Zhao

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  13. Marine biomaterials in biomedical nano/micro-systems.Journal of nanobiotechnology · 2023
    Review
  14. Melanin-Integrated Structural Color Hybrid Hydrogels for Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xinyue CaoDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Zhuohao ZhangDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Lingyu SunDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Zhiqiang LuoDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Yuanjin ZhaoDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China. yjzhao@seu.edu.cn.

Funding

Guangdong Basic and Applied Basic Research Foundation 2021B1515120054National Key Research and Development Program of China 2020YFA0908200National Natural Science Foundation of China 52073060National Natural Science Foundation of China 61927805Shenzhen Fundamental Research Program JCYJ20190813152616459Shenzhen Fundamental Research Program JCYJ20210324133214038
6 · The paper itself

Abstract

backgroundWound healing has become a worldwide healthcare issue. Attempts in the area focus on developing patches with the capabilities of avoiding wound infection, promoting tissue remolding, and reporting treatment status that are of great value for wound treatment.

resultsIn this paper, we present a novel inverse opal film (IOF) patch based on a photo-crosslinking fish gelatin hydrogel with the desired features for wound healing and dynamic monitoring. The film with vibrant structure colors was constructed by using the mixture of fish gelatin methacryloyl, chitosan, and polyacrylic acid (PAA) to replicate colloidal crystal templates. As the structures of these natural biomolecules are well-retained during the fabrication, the resultant IOF was with brilliant biocompatibility, low immunogenicity, antibacterial property, as well as with the functions of promoting tissue growth and wound healing. In addition, the IOF presented interconnected nanopores and high specific surface areas for vascular endothelial growth factor loading, which could further improve its angiogenesis capability. More attractively, as the pH-responsive PAA was incorporated, the IOF patch could report the wound healing status through its real-time structural colors or reflectance spectra.

conclusionsThese features implied the practical value of the multifunctional fish gelatin hydrogel IOFs in clinical wound management.

Indexed as

GelatinHydrogelsAnimalsAnti-Bacterial AgentsMethacrylatesVascular Endothelial Growth Factor AWound HealingAnti-Bacterial AgentsGelatingelatin methacryloylHydrogelsMethacrylatesVascular Endothelial Growth Factor AFish gelatinHydrogelPatchSensorStructural colorWound healing

Identifiers

PMID35918727
PMCPMC9344764

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.