ArticleBMC geriatrics2022
Sleep duration, genetic susceptibility, and Alzheimer's disease: a longitudinal UK Biobank-based study.
Article in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Sleep characteristics and risk of Alzheimer's disease: a systematic review and meta-analysis of longitudinal studies.Journal of neurology · 2024Pooled it
- Article
- The combined association between sleep duration and insomnia symptoms with dementia and cognitive deficits: a multivariable-adjusted and genetic liability study.GeroScience · 2026Article
- Sleep and dementia: Assessing established dementia-related factors using multivariable Mendelian randomization.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Reconstructing cerebral lymphatic clearance: an emerging target in the Alzheimer's disease therapeutic pipeline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Association of Sleep Duration, Metabolic Markers, and Risk of All-Cause and Cause-Specific Mortality in China and the UK.Global heart · 2026Article
- Article
- Polygenic score for sleep duration in relation to the risk of Alzheimer's disease: results from the UK biobank.Frontiers in dementia · 2026Article
- Association of Income Inequality and Sleep Duration With Cardiovascular Outcomes in China and the UK.JACC. Asia · 2025Article
- Associations of adherence to a healthy sleep pattern with the dementia risk in the UK biobank.Alzheimer's research & therapy · 2025Article
- Biomarker identification for Alzheimer's disease through integration of comprehensive Mendelian randomization and proteomics data.Journal of translational medicine · 2025Article
- Dose-response associations of device-measured sleep regularity and duration with incident dementia in 82391 UK adults.BMC public health · 2025Article
- Association between sleep duration, sleep trouble and all-cause mortality in individuals with hyperuricemia in the United States.Frontiers in public health · 2025Article
- Association of self-reported sleep duration with leukocyte telomere length in type 2 diabetes mellitus patients.Frontiers in endocrinology · 2025Article
- Reduction of orexin-expressing neurons and a unique sleep phenotype in the Tg-SwDI mouse model of Alzheimer's disease.Frontiers in aging neuroscience · 2025Article
- Mendelian randomization study of self-reported long sleep duration, short sleep duration, and insomnia and cognitive function.PloS one · 2025Article
- Investigating Modifiable Risk Factors Across Dementia Subtypes: Insights from the UK Biobank.Biomedicines · 2024Article
- Association between Sleep Duration, Social Jetlag, and the Metabolic Syndrome by Shift Works.International journal of environmental research and public health · 2024Article
- Article
- Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlzheimer's disease (AD) is the most frequently occurring type of dementia. Concurrently, inadequate sleep has been recognized as a public health epidemic. Notably, genetic and environmental factors are now considered contributors to AD progression.
objectiveTo assess the association between sleep duration, genetic susceptibility, and AD. METHODS AND
resultsBased on 483,507 participants from the UK Biobank (UKB) with an average follow-up of 11.3 years, there was a non-linear relationship between AD incidence and sleep duration (P for non-linear < 0.001) by restricted cubic splines (RCS). Sleep duration was categorized into short sleep duration (< 6 h/night), normal sleep duration (6-9 h/night), and long sleep duration (> 9 h/night). No statistically significant interaction was identified between sleep duration and the AD-GRS (Alzheimer's disease genetic risk score, P for interaction = 0.45) using Cox proportional risk model. Compared with the participants who had a low AD-GRS and normal sleep duration, there was associated with a higher risk of AD in participants with a low AD-GRS and long sleep duration (HR = 3.4806; 95% CI 2.0011-6.054, p < 0.001), participants with an intermediate AD-GRS and long sleep duration (HR = 2.0485; 95% CI 1.3491-3.1105, p < 0.001), participants with a high AD-GRS and normal sleep duration (HR = 1.9272; 95% CI 1.5361-2.4176, p < 0.001), and participants with a high AD-GRS and long sleep duration (HR = 5.4548; 95% CI 3.1367-9.4863, p < 0.001).In addition, there was no causal association between AD and sleep duration using Two Sample Mendelian randomization (MR).
conclusionIn the UKB population, though there was no causal association between AD and sleep duration analyzed using Two Sample MR, long sleep duration (> 9 h/night) was significantly associated with a higher risk of AD, regardless of high, intermediate or low AD-GRS. Prolonged sleep duration may be one of the clinical predictors of a higher risk of AD.
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