ArticleEmergency radiology2022
Rapidly progressive interstitial lung disease in patients with anti-melanoma differentiation-associated gene 5-positive dermatomyositis: serial changes on HRCT.
Article in Emergency radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Interstitial lung disease in systemic autoimmune rheumatic diseases: radiologic and histologic correlations.Rheumatology advances in practice · 2026Article
- Severe interstitial lung disease risk prediction in anti-melanoma differentiation-associated protein 5 positive dermatomyositis: the STRAD-Ro52 model.Annals of medicine · 2025Article
- Anti MDA-5 associated rapidly progressive interstitial lung disease complicated by viral pneumonia - a fatal outcome.Autopsy & case reports · 2024Article
- Clinical nomogram assisting in discrimination of juvenile dermatomyositis-associated interstitial lung disease.Respiratory research · 2023Article
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9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAnti-melanoma differentiation-associated gene 5 (anti-MDA5) antibodies in patients with dermatomyositis are associated with rapidly progressive interstitial lung disease (RP-ILD). Computed tomography (CT) plays a central role in the diagnosis of RP-ILD and may help characterize the temporal changes.
methodsWe report five anti-MDA5-positive dermatomyositis patients with serial CT scans spanning their acute RP-ILD disease course.
resultsOur case series highlights the variable imaging pattern that can manifest in this setting, including diffuse alveolar damage and nonspecific interstitial pneumonia patterns. Three patients in our series died within 4 months of their disease onset, whereas the other two patients survived.
conclusionThe serial CT changes in anti-MDA5 disease are dynamic and variable; therefore, it is imperative to maintain a broad differential when faced with these HRCT patterns to improve the diagnosis and management of this underrecognized entity.
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