Evidence map›Paper›PMID 35918561›Full record

ArticleAAPS PharmSciTech2022

Development and Characterization of Celecoxib Solid Self-nanoemulsifying Drug Delivery Systems (S-SNEDDS) Prepared Using Novel Cellulose-Based Microparticles as Adsorptive Carriers.

Fabian-Pascal Schmied, Alexander Bernhardt, Victor Baudron, Birte Beine, Sandra Klein

Abstract read
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In one paragraph

Article in AAPS PharmSciTech, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fabian-Pascal SchmiedUniversity of Greifswald, Department of Pharmacy, Institute of Biopharmaceutics and Pharmaceutical Technology, Felix-Hausdorff-Straße 3, 17489, Greifswald, Germany.
Alexander BernhardtEvonik Operations GmbH, Research, Development & Innovation, Kirschenallee, 64293, Darmstadt, Germany.
Victor BaudronEvonik Operations GmbH, Research, Development & Innovation, Rodenbacher Chaussee 4, 63457, Hanau, Germany.
Birte BeineEvonik Operations GmbH, Research, Development & Innovation, Paul-Baumann-Str. 1, 55772, Marl, Germany.
Sandra KleinUniversity of Greifswald, Department of Pharmacy, Institute of Biopharmaceutics and Pharmaceutical Technology, Felix-Hausdorff-Straße 3, 17489, Greifswald, Germany. Sandra.Klein@uni-greifswald.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Self-nanoemulsifying drug delivery systems (SNEDDS) represent an interesting platform for improving the oral bioavailability of poorly soluble lipophilic drugs. While Liquid-SNEDDS (L-SNEDDS) effectively solubilize the drug in vivo, they have several drawbacks, including poor storage stability. Solid-SNEDDS (S-SNEDDS) combine the advantages of L-SNEDDS with those of solid dosage forms, particularly stability. The aim of the present study was to convert celecoxib L-SNEDDS into S-SNEDDS without altering their release behavior. Various commercially available adsorptive carrier materials were investigated, as well as novel cellulose-based microparticles prepared by spray drying from an aqueous dispersion containing Diacel

Indexed as

CelluloseNanoparticlesAdministration, OralBiological AvailabilityCelecoxibDrug CarriersDrug Delivery SystemsEmulsionsExcipientsParticle SizeSolubilityCelecoxibCelluloseDrug CarriersEmulsionsExcipientsCelluloseDrug releaseL-SNEDDSPoorly soluble drugsScanning electron microscopy

Identifiers

PMID35918561

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.