Evidence map›Paper›PMID 35918531›Full record

ArticlePsychopharmacology2022

An interaction between basolateral amygdala orexinergic and endocannabinoid systems in inducing anti-nociception in the rat formalin test.

Soghra Borneh Deli, Samira Iman Bonab, Roghaieh Khakpay, Fatemeh Khakpai, Mohammadali Hosseinpour Feyzi

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Soghra Borneh DeliDepartment of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Samira Iman BonabDepartment of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Roghaieh KhakpayDepartment of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. rkhakpai@gmail.com.ORCID http://orcid.org/0000-0002-8845-8045
Fatemeh KhakpaiCognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Mohammadali Hosseinpour FeyziDepartment of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
University of Tabriz · IRIslamic Azad University Medical Branch of Tehran · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The amygdala has emerged as the main brain center for the emotional affective dimension of pain and pain modulation. In the amygdala, orexin and cannabinoid receptors are expressed in relatively high concentrations. To investigate the possible interaction between the amygdala orexin and cannabinoid systems on the modulation of inflammatory pain, we conducted formalin, rotarod, and plethysmometer tests, as well as analyzing mRNA expression of orexin and cannabinoid receptors in male rats. The basolateral amygdala (BLA) was unilaterally implanted by a guide cannula. Our results showed that, compared to saline and DMSO/saline, intra-BLA microinjection of orexin-A (50 and 100 µM) decreased flinch response in the early phase, but not in the late phase of the formalin test. However, these injections had no significant effect on the mRNA expression level of BLA, orexin receptor type-1 (Orx

Indexed as

Basolateral Nuclear ComplexCannabinoidsAnimalsBenzoxazolesDimethyl SulfoxideEndocannabinoidsFormaldehydeMaleNaphthyridinesOrexin ReceptorsOrexinsPainPain MeasurementRatsRats, WistarReceptor, Cannabinoid, CB11-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl ureaBenzoxazolesCannabinoidsDimethyl SulfoxideEndocannabinoidsFormaldehydeNaphthyridinesOrexin ReceptorsOrexinsReceptor, Cannabinoid, CB1RNA, MessengerUreaBLACb1 receptorFormalinOrx1 receptorPain

Identifiers

PMID35918531
OpenAlexW4289517297

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.