Evidence map›Paper›PMID 35918503›Full record

SynthesisAnnals of the New York Academy of Sciences2022

Melodic Intonation Therapy for aphasia: A multi-level meta-analysis of randomized controlled trials and individual participant data.

Tudor Popescu, Benjamin Stahl, Brenton M Wiernik, Felix Haiduk, Michaela Zemanek, Hannah Helm, Theresa Matzinger, Roland Beisteiner, W Tecumseh Fitch

Registry-linked trialOpen access · hybridAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of the New York Academy of Sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05845047 (PICTURE IT), which is not on this map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05845047 narecruitingnot on this mapstarted 2023, after this paper: background citation

PICTURE IT: Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine

TypeinterventionalSponsorJohns Hopkins UniversityRan2023 to 2031Enrolled70ConditionsAphasia, StrokeArmsPICTURE-IT, CoDeLT
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Neurology of social graces in patients with language deficits.Journal of neurology, neurosurgery, and psychiatry · 2026
    Article
  7. Neurorehabilitation Clinical Pathways in Stroke: The Padova Model.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 5 countries.

Tudor PopescuDepartment of Behavioural and Cognitive Biology, University of Vienna, Vienna, Austria.ORCID 0000-0001-5890-1520
Benjamin StahlFaculty of Science, Medical School Berlin, Berlin, Germany.ORCID 0000-0003-3957-1495
Brenton M WiernikDepartment of Psychology, University of South Florida, Tampa, Florida, USA.ORCID 0000-0001-9560-6336
Felix HaidukDepartment of Behavioural and Cognitive Biology, University of Vienna, Vienna, Austria.
Michaela ZemanekUniversity Library, University of Vienna, Vienna, Austria.
Hannah HelmFaculty of Science, Medical School Berlin, Berlin, Germany.
Theresa MatzingerDepartment of Behavioural and Cognitive Biology, University of Vienna, Vienna, Austria.ORCID 0000-0001-5414-7962
Roland BeisteinerDepartment of Neurology, Medical University of Vienna, Vienna, Austria.
W Tecumseh FitchDepartment of Behavioural and Cognitive Biology, University of Vienna, Vienna, Austria.ORCID 0000-0003-1830-0928
University of Vienna · ATMedical University of Vienna · ATMSB Medical School Berlin · DEUniversitätsmedizin Greifswald · DEUniversity of South Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melodic Intonation Therapy (MIT) is a prominent rehabilitation program for individuals with post-stroke aphasia. Our meta-analysis investigated the efficacy of MIT while considering quality of outcomes, experimental design, influence of spontaneous recovery, MIT protocol variant, and level of generalization. Extensive literature search identified 606 studies in major databases and trial registers; of those, 22 studies-overall 129 participants-met all eligibility criteria. Multi-level mixed- and random-effects models served to separately meta-analyze randomized controlled trial (RCT) and non-RCT data. RCT evidence on validated outcomes revealed a small-to-moderate standardized effect in noncommunicative language expression for MIT-with substantial uncertainty. Unvalidated outcomes attenuated MIT's effect size compared to validated tests. MIT's effect size was 5.7 times larger for non-RCT data compared to RCT data (g̅

Indexed as

AphasiaStrokeHumansLanguageRandomized Controlled Trials as TopicSpeech Therapyapraxia of speechexperimental designformulaic languageMelodic Intonation Therapymeta-analysispost-stroke aphasiarhythmic pacingsinging

Identifiers

PMID35918503
PMCPMC9804200
OpenAlexW4289520618

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.