Evidence map›Paper›PMID 35918458›Full record

ArticleBrain structure & function2022

Analysis of lateral orbitofrontal cortex activation on acquisition of fear extinction and neuronal activities in fear circuit.

Cheng-Chia Shih, Yu-Hsuan Chang, Ruei-Jen Chiou, Chun-Hui Chang

Abstract read
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In one paragraph

Article in Brain structure & function, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Cheng-Chia ShihInstitute of Systems Neuroscience, National Tsing Hua University, Kuang-Fu Rd, Sec 2, No 101, Hsinchu, 30013, Taiwan.
Yu-Hsuan ChangInstitute of Systems Neuroscience, National Tsing Hua University, Kuang-Fu Rd, Sec 2, No 101, Hsinchu, 30013, Taiwan.
Ruei-Jen ChiouDepartment of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Chun-Hui ChangInstitute of Systems Neuroscience, National Tsing Hua University, Kuang-Fu Rd, Sec 2, No 101, Hsinchu, 30013, Taiwan. changch@life.nthu.edu.tw.ORCID http://orcid.org/0000-0003-0914-2518
National Tsing Hua University · TWTaipei Medical University · TW

Funding

Ministry of Science and Technology, Taiwan MOST 106-2320-B-007-006-MY3Ministry of Science and Technology, Taiwan MOST 110-2628-B-007-002
6 · The paper itself

Abstract

Inappropriate fear expression and failure of fear extinction are commonly seen in patients with post-traumatic stress disorder (PTSD) and obsessive-compulsive disorder (OCD). Among the patients, aberrant and asymmetric activation of the lateral orbitofrontal cortex (lOFC) is reported in some clinical cases. In this study, we aimed to examine the role of lOFC activation in extinction acquisition and explore the potential functional lateralization of lOFC on extinction. We bilaterally or unilaterally activated the lOFC with N-methyl-

Indexed as

Extinction, PsychologicalFearAmygdalaAnimalsNeuronsPrefrontal CortexRatsBehavioral pharmacologyFear extinctionFunctional lateralizationObsessive-compulsive disorderOrbitofrontal cortex

Identifiers

PMID35918458
OpenAlexW4289521777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.