Evidence map›Paper›PMID 35918348›Full record

ArticleNature communications2022

Flexible-type ultrathin holographic endoscope for microscopic imaging of unstained biological tissues.

Wonjun Choi, Munkyu Kang, Jin Hee Hong, Ori Katz, Byunghak Lee, Guang Hoon Kim, Youngwoon Choi, Wonshik Choi

Abstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  13. Quantitative phase imaging endoscopy with a metalens.Light, science & applications · 2024
    Article
  14. Advancing the path toNeurophotonics · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wonjun Choi *Center for Molecular Spectroscopy and Dynamics, Institute for Basic Science, Seoul, Republic of Korea.
Munkyu Kang *Center for Molecular Spectroscopy and Dynamics, Institute for Basic Science, Seoul, Republic of Korea.
Jin Hee HongCenter for Molecular Spectroscopy and Dynamics, Institute for Basic Science, Seoul, Republic of Korea.
Ori KatzDepartment of Applied Physics, The Selim and Rachel Benin School of Computer Science & Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.
Byunghak LeeKorea Electrotechnology Research Institute, Ansan, Korea.ORCID 0000-0003-3555-0910
Guang Hoon KimKorea Electrotechnology Research Institute, Ansan, Korea.
Youngwoon ChoiDepartment of Bioengineering, Korea University, Seoul, Republic of Korea. youngwoon@korea.ac.kr.ORCID 0000-0001-8492-8225
Wonshik ChoiCenter for Molecular Spectroscopy and Dynamics, Institute for Basic Science, Seoul, Republic of Korea. wonshik@korea.ac.kr.ORCID 0000-0002-9445-7081

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultrathin lensless fibre endoscopes offer minimally invasive investigation, but they mostly operate as a rigid type due to the need for prior calibration of a fibre probe. Furthermore, most implementations work in fluorescence mode rather than label-free imaging mode, making them unsuitable for general medical diagnosis. Herein, we report a fully flexible ultrathin fibre endoscope taking 3D holographic images of unstained tissues with 0.85-μm spatial resolution. Using a bare fibre bundle as thin as 200-μm diameter, we design a lensless Fourier holographic imaging configuration to selectively detect weak reflections from biological tissues, a critical step for label-free endoscopic reflectance imaging. A unique algorithm is developed for calibration-free holographic image reconstruction, allowing us to image through a narrow and curved passage regardless of fibre bending. We demonstrate endoscopic reflectance imaging of unstained rat intestine tissues that are completely invisible to conventional endoscopes. The proposed endoscope will expedite a more accurate and earlier diagnosis than before with minimal complications.

Indexed as

EndoscopesHolographyAnimalsEndoscopyImage Processing, Computer-AssistedImaging, Three-DimensionalRats

Identifiers

PMID35918348
PMCPMC9345988

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.