Evidence map›Paper›PMID 35918247›Full record

ReviewTrends in microbiology2023

Monoclonal antibodies to lipoarabinomannan/arabinomannan - characteristics and implications for tuberculosis research and diagnostics.

Devin T Corrigan, Elise Ishida, Delphi Chatterjee, Todd L Lowary, Jacqueline M Achkar

Open access · greenAbstract readReview
In one paragraph

Review in Trends in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Devin T CorriganDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Elise IshidaDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Delphi ChatterjeeMycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA.
Todd L LowaryInstitute of Biological Chemistry, Academia Sinica, Nangang Taipei, Taiwan; Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan.
Jacqueline M AchkarDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: jacqueline.achkar@einsteinmed.edu.
Albert Einstein College of Medicine · USColorado State University · USNational Taiwan University · TW

Funding

CTSA Administrative Supplement for Informatics Core: A novel AI/ML system to predict respiratory failure and ARDS in Covid-19 patientsUL1TR002556 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, KIM, MIMI Y · 2018 to 2022
$26.7M
Geographic Medicine and Emerging InfectionsT32AI070117 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WEISS, LOUIS M. · 2008 to 2023
$5.1M
Characteristics and protective efficacy of human antibodies against M. tuberculosisR01AI146329 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI ACHKAR, JACQUELINE MICHELE · 2019 to 2023
$3.9M
Host biomarkers for M. tuberculosis infection activity in HIV-infected personsR01AI117927 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ACHKAR, JACQUELINE MICHELE · 2016 to 2020
$3.6M
Validation of urine/serum LAM in HIV/nonHIV TB suspects and POC Test DevelopmentR01AI132680 · NIAID · COLORADO STATE UNIVERSITY · PI CHATTERJEE, DELPHI · 2018 to 2021
$2.3M
NRSA Training CoreTL1TR002557 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MARANTZ, PAUL R · 2018 to 2022
$1.0M
Clinical and Translational Science AwardTL1TR001072 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SHAMOON, HARRY · 2013 to 2017
$909k
Antibodies associated with protection against tuberculosis in nonhuman primatesR21AI127173 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ACHKAR, JACQUELINE MICHELE · 2017 to 2018
$473k
NCATS NIH HHS TL1 TR001072NCATS NIH HHS TL1 TR002557NCATS NIH HHS UL1 TR002556NIAID NIH HHS R01 AI117927NIAID NIH HHS R01 AI132680NIAID NIH HHS R01 AI146329NIAID NIH HHS R21 AI127173NIAID NIH HHS T32 AI070117
6 · The paper itself

Abstract

Antibodies to the mycobacterial surface lipoglycan lipoarabinomannan (LAM) and its related capsular polysaccharide arabinomannan (AM) are increasingly important for investigations focused on both understanding mechanisms of protection against Mycobacterium tuberculosis (Mtb) and developing next-generation point-of-care tuberculosis (TB) diagnostics. We provide here an overview of the growing pipeline of monoclonal antibodies (mAbs) to LAM/AM. Old and new methodologies for their generation are reviewed and we outline and discuss their glycan epitope specificity and other features with implications for the TB field.

Indexed as

Mycobacterium tuberculosisTuberculosisAntibodies, MonoclonalHumansLipopolysaccharidesMannansAntibodies, MonoclonalarabinomannanlipoarabinomannanLipopolysaccharidesMannansantigen–antibody interactionsbiomarkerglycanslipoglycansmycobacteriaoligosaccharidespoint-of-care tests

Identifiers

PMID35918247
PMCPMC9771891
OpenAlexW4288844229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.