Evidence map›Paper›PMID 35918164›Full record

Trial reportNeurology2022

Time Since Stroke Onset, Quantitative Collateral Score, and Functional Outcome After Endovascular Treatment for Acute Ischemic Stroke.

Simone M Uniken Venema, Lennard Wolff, Sophie A van den Berg, Hendrik Reinink, Sven P R Luijten, Hester F Lingsma, Henk A Marquering, Anna M M Boers, Joost Bot, Sebastiaan Hammer and 7 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. TREAT-AIS: A Multicenter National Registry.Stroke (Hoboken, N.J.) · 2023
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Simone M Uniken VenemaFrom the Departments of Neurology and Neurosurgery (S.M.U.V., H.R., H.B.v.d.W.), Brain Center, and Department of Radiology (J.W.D.), University Medical Center Utrecht; Departments of Radiology & Nuclear Medicine (L.W., S.P.R.L., A.v.d.L.), Public Health (H.F.L.), Erasmus MC, University Medical Center, Rotterdam; Departments of Neurology (S.A.v.d.B., P.J.N., Y.B.W.E.M.R.), Radiology and Nuclear Medicine (H.A.M., A.B.), Radiology and Nuclear Medicine (J.B., C.B.L.M.M.), and Biomedical Engineering & Physics (H.A.M., A.M.M.B.), Amsterdam University Medical Centers, University of Amsterdam; and Department of Radiology (S.H.), Haga Ziekenhuis, The Hague, the Netherlands s.m.unikenvenema@umcutrecht.nl.
Lennard WolffFrom the Departments of Neurology and Neurosurgery (S.M.U.V., H.R., H.B.v.d.W.), Brain Center, and Department of Radiology (J.W.D.), University Medical Center Utrecht; Departments of Radiology & Nuclear Medicine (L.W., S.P.R.L., A.v.d.L.), Public Health (H.F.L.), Erasmus MC, University Medical Center, Rotterdam; Departments of Neurology (S.A.v.d.B., P.J.N., Y.B.W.E.M.R.), Radiology and Nuclear Medicine (H.A.M., A.B.), Radiology and Nuclear Medicine (J.B., C.B.L.M.M.), and Biomedical Engineering & Physics (H.A.M., A.M.M.B.), Amsterdam University Medical Centers, University of Amsterdam; and Department of Radiology (S.H.), Haga Ziekenhuis, The Hague, the Netherlands.
Sophie A van den BergFrom the Departments of Neurology and Neurosurgery (S.M.U.V., H.R., H.B.v.d.W.), Brain Center, and Department of Radiology (J.W.D.), University Medical Center Utrecht; Departments of Radiology & Nuclear Medicine (L.W., S.P.R.L., A.v.d.L.), Public Health (H.F.L.), Erasmus MC, University Medical Center, Rotterdam; Departments of Neurology (S.A.v.d.B., P.J.N., Y.B.W.E.M.R.), Radiology and Nuclear Medicine (H.A.M., A.B.), Radiology and Nuclear Medicine (J.B., C.B.L.M.M.), and Biomedical Engineering & Physics (H.A.M., A.M.M.B.), Amsterdam University Medical Centers, University of Amsterdam; and Department of Radiology (S.H.), Haga Ziekenhuis, The Hague, the Netherlands.
Hendrik ReininkFrom the Departments of Neurology and Neurosurgery (S.M.U.V., H.R., H.B.v.d.W.), Brain Center, and Department of Radiology (J.W.D.), University Medical Center Utrecht; Departments of Radiology & Nuclear Medicine (L.W., S.P.R.L., A.v.d.L.), Public Health (H.F.L.), Erasmus MC, University Medical Center, Rotterdam; Departments of Neurology (S.A.v.d.B., P.J.N., Y.B.W.E.M.R.), Radiology and Nuclear Medicine (H.A.M., A.B.), Radiology and Nuclear Medicine (J.B., C.B.L.M.M.), and Biomedical Engineering & Physics (H.A.M., A.M.M.B.), Amsterdam University Medical Centers, University of Amsterdam; and Department of Radiology (S.H.), Haga Ziekenhuis, The Hague, the Netherlands.
Sven P R LuijtenFrom the Departments of Neurology and Neurosurgery (S.M.U.V., H.R., H.B.v.d.W.), Brain Center, and Department of Radiology (J.W.D.), University Medical Center Utrecht; Departments of Radiology & Nuclear Medicine (L.W., S.P.R.L., A.v.d.L.), Public Health (H.F.L.), Erasmus MC, University Medical Center, Rotterdam; Departments of Neurology (S.A.v.d.B., P.J.N., Y.B.W.E.M.R.), Radiology and Nuclear Medicine (H.A.M., A.B.), Radiology and Nuclear Medicine (J.B., C.B.L.M.M.), and Biomedical Engineering & Physics (H.A.M., A.M.M.B.), Amsterdam University Medical Centers, University of Amsterdam; and Department of Radiology (S.H.), Haga Ziekenhuis, The Hague, the Netherlands.
Hester F LingsmaFrom the Departments of Neurology and Neurosurgery (S.M.U.V., H.R., H.B.v.d.W.), Brain Center, and Department of Radiology (J.W.D.), University Medical Center Utrecht; Departments of Radiology & Nuclear Medicine (L.W., S.P.R.L., A.v.d.L.), Public Health (H.F.L.), Erasmus MC, University Medical Center, Rotterdam; Departments of Neurology (S.A.v.d.B., P.J.N., Y.B.W.E.M.R.), Radiology and Nuclear Medicine (H.A.M., A.B.), Radiology and Nuclear Medicine (J.B., C.B.L.M.M.), and Biomedical Engineering & Physics (H.A.M., A.M.M.B.), Amsterdam University Medical Centers, University of Amsterdam; and Department of Radiology (S.H.), Haga Ziekenhuis, The Hague, the Netherlands.
Henk A MarqueringFrom the Departments of Neurology and Neurosurgery (S.M.U.V., H.R., H.B.v.d.W.), Brain Center, and Department of Radiology (J.W.D.), University Medical Center Utrecht; Departments of Radiology & Nuclear Medicine (L.W., S.P.R.L., A.v.d.L.), Public Health (H.F.L.), Erasmus MC, University Medical Center, Rotterdam; Departments of Neurology (S.A.v.d.B., P.J.N., Y.B.W.E.M.R.), Radiology and Nuclear Medicine (H.A.M., A.B.), Radiology and Nuclear Medicine (J.B., C.B.L.M.M.), and Biomedical Engineering & Physics (H.A.M., A.M.M.B.), Amsterdam University Medical Centers, University of Amsterdam; and Department of Radiology (S.H.), Haga Ziekenhuis, The Hague, the Netherlands.ORCID 0000-0002-1414-6313
Anna M M BoersFrom the Departments of Neurology and Neurosurgery (S.M.U.V., H.R., H.B.v.d.W.), Brain Center, and Department of Radiology (J.W.D.), University Medical Center Utrecht; Departments of Radiology & Nuclear Medicine (L.W., S.P.R.L., A.v.d.L.), Public Health (H.F.L.), Erasmus MC, University Medical Center, Rotterdam; Departments of Neurology (S.A.v.d.B., P.J.N., Y.B.W.E.M.R.), Radiology and Nuclear Medicine (H.A.M., A.B.), Radiology and Nuclear Medicine (J.B., C.B.L.M.M.), and Biomedical Engineering & Physics (H.A.M., A.M.M.B.), Amsterdam University Medical Centers, University of Amsterdam; and Department of Radiology (S.H.), Haga Ziekenhuis, The Hague, the Netherlands.
Joost BotFrom the Departments of Neurology and Neurosurgery (S.M.U.V., H.R., H.B.v.d.W.), Brain Center, and Department of Radiology (J.W.D.), University Medical Center Utrecht; Departments of Radiology & Nuclear Medicine (L.W., S.P.R.L., A.v.d.L.), Public Health (H.F.L.), Erasmus MC, University Medical Center, Rotterdam; Departments of Neurology (S.A.v.d.B., P.J.N., Y.B.W.E.M.R.), Radiology and Nuclear Medicine (H.A.M., A.B.), Radiology and Nuclear Medicine (J.B., C.B.L.M.M.), and Biomedical Engineering & Physics (H.A.M., A.M.M.B.), Amsterdam University Medical Centers, University of Amsterdam; and Department of Radiology (S.H.), Haga Ziekenhuis, The Hague, the Netherlands.
Sebastiaan HammerFrom the Departments of Neurology and Neurosurgery (S.M.U.V., H.R., H.B.v.d.W.), Brain Center, and Department of Radiology (J.W.D.), University Medical Center Utrecht; Departments of Radiology & Nuclear Medicine (L.W., S.P.R.L., A.v.d.L.), Public Health (H.F.L.), Erasmus MC, University Medical Center, Rotterdam; Departments of Neurology (S.A.v.d.B., P.J.N., Y.B.W.E.M.R.), Radiology and Nuclear Medicine (H.A.M., A.B.), Radiology and Nuclear Medicine (J.B., C.B.L.M.M.), and Biomedical Engineering & Physics (H.A.M., A.M.M.B.), Amsterdam University Medical Centers, University of Amsterdam; and Department of Radiology (S.H.), Haga Ziekenhuis, The Hague, the Netherlands.
Paul J NederkoornFrom the Departments of Neurology and Neurosurgery (S.M.U.V., H.R., H.B.v.d.W.), Brain Center, and Department of Radiology (J.W.D.), University Medical Center Utrecht; Departments of Radiology & Nuclear Medicine (L.W., S.P.R.L., A.v.d.L.), Public Health (H.F.L.), Erasmus MC, University Medical Center, Rotterdam; Departments of Neurology (S.A.v.d.B., P.J.N., Y.B.W.E.M.R.), Radiology and Nuclear Medicine (H.A.M., A.B.), Radiology and Nuclear Medicine (J.B., C.B.L.M.M.), and Biomedical Engineering & Physics (H.A.M., A.M.M.B.), Amsterdam University Medical Centers, University of Amsterdam; and Department of Radiology (S.H.), Haga Ziekenhuis, The Hague, the Netherlands.
Yvo B W E M RoosFrom the Departments of Neurology and Neurosurgery (S.M.U.V., H.R., H.B.v.d.W.), Brain Center, and Department of Radiology (J.W.D.), University Medical Center Utrecht; Departments of Radiology & Nuclear Medicine (L.W., S.P.R.L., A.v.d.L.), Public Health (H.F.L.), Erasmus MC, University Medical Center, Rotterdam; Departments of Neurology (S.A.v.d.B., P.J.N., Y.B.W.E.M.R.), Radiology and Nuclear Medicine (H.A.M., A.B.), Radiology and Nuclear Medicine (J.B., C.B.L.M.M.), and Biomedical Engineering & Physics (H.A.M., A.M.M.B.), Amsterdam University Medical Centers, University of Amsterdam; and Department of Radiology (S.H.), Haga Ziekenhuis, The Hague, the Netherlands.ORCID 0000-0001-9205-5882
Charles B L M MajoieFrom the Departments of Neurology and Neurosurgery (S.M.U.V., H.R., H.B.v.d.W.), Brain Center, and Department of Radiology (J.W.D.), University Medical Center Utrecht; Departments of Radiology & Nuclear Medicine (L.W., S.P.R.L., A.v.d.L.), Public Health (H.F.L.), Erasmus MC, University Medical Center, Rotterdam; Departments of Neurology (S.A.v.d.B., P.J.N., Y.B.W.E.M.R.), Radiology and Nuclear Medicine (H.A.M., A.B.), Radiology and Nuclear Medicine (J.B., C.B.L.M.M.), and Biomedical Engineering & Physics (H.A.M., A.M.M.B.), Amsterdam University Medical Centers, University of Amsterdam; and Department of Radiology (S.H.), Haga Ziekenhuis, The Hague, the Netherlands.ORCID 0000-0002-7600-9568
Jan Willem DankbaarFrom the Departments of Neurology and Neurosurgery (S.M.U.V., H.R., H.B.v.d.W.), Brain Center, and Department of Radiology (J.W.D.), University Medical Center Utrecht; Departments of Radiology & Nuclear Medicine (L.W., S.P.R.L., A.v.d.L.), Public Health (H.F.L.), Erasmus MC, University Medical Center, Rotterdam; Departments of Neurology (S.A.v.d.B., P.J.N., Y.B.W.E.M.R.), Radiology and Nuclear Medicine (H.A.M., A.B.), Radiology and Nuclear Medicine (J.B., C.B.L.M.M.), and Biomedical Engineering & Physics (H.A.M., A.M.M.B.), Amsterdam University Medical Centers, University of Amsterdam; and Department of Radiology (S.H.), Haga Ziekenhuis, The Hague, the Netherlands.ORCID 0000-0003-4646-9587
Aad van der LugtFrom the Departments of Neurology and Neurosurgery (S.M.U.V., H.R., H.B.v.d.W.), Brain Center, and Department of Radiology (J.W.D.), University Medical Center Utrecht; Departments of Radiology & Nuclear Medicine (L.W., S.P.R.L., A.v.d.L.), Public Health (H.F.L.), Erasmus MC, University Medical Center, Rotterdam; Departments of Neurology (S.A.v.d.B., P.J.N., Y.B.W.E.M.R.), Radiology and Nuclear Medicine (H.A.M., A.B.), Radiology and Nuclear Medicine (J.B., C.B.L.M.M.), and Biomedical Engineering & Physics (H.A.M., A.M.M.B.), Amsterdam University Medical Centers, University of Amsterdam; and Department of Radiology (S.H.), Haga Ziekenhuis, The Hague, the Netherlands.ORCID 0000-0002-6159-2228
H Bart van der WorpFrom the Departments of Neurology and Neurosurgery (S.M.U.V., H.R., H.B.v.d.W.), Brain Center, and Department of Radiology (J.W.D.), University Medical Center Utrecht; Departments of Radiology & Nuclear Medicine (L.W., S.P.R.L., A.v.d.L.), Public Health (H.F.L.), Erasmus MC, University Medical Center, Rotterdam; Departments of Neurology (S.A.v.d.B., P.J.N., Y.B.W.E.M.R.), Radiology and Nuclear Medicine (H.A.M., A.B.), Radiology and Nuclear Medicine (J.B., C.B.L.M.M.), and Biomedical Engineering & Physics (H.A.M., A.M.M.B.), Amsterdam University Medical Centers, University of Amsterdam; and Department of Radiology (S.H.), Haga Ziekenhuis, The Hague, the Netherlands.ORCID 0000-0001-9891-2136
MR CLEAN Registry Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesIn patients with ischemic stroke undergoing endovascular treatment (EVT), time to treatment and collateral status are important prognostic factors and may be correlated. We aimed to assess the relation between time to CT angiography (CTA) and a quantitatively determined collateral score and to assess whether the collateral score modified the relation between time to recanalization and functional outcome.

methodsWe analyzed data from patients with acute ischemic stroke included in the Multicenter Randomized Controlled Trial of Endovascular Treatment for Acute Ischemic Stroke Registry between 2014 and 2017, who had a carotid terminus or M1 occlusion and were treated with EVT within 6.5 hours of symptom onset. A quantitative collateral score (qCS) was determined from baseline CTA using a validated automated image analysis algorithm. We also determined a 4-point visual collateral score (vCS). Multivariable regression models were used to assess the relations between time to imaging and the qCS and between the time to recanalization and functional outcome (90-day modified Rankin Scale score). An interaction term (time to recanalization × qCS) was entered in the latter model to test whether the qCS modifies this relation. Sensitivity analyses were performed using the vCS.

resultsWe analyzed 1,813 patients. The median time from symptom onset to CTA was 91 minutes (interquartile range [IQR] 65-150 minutes), and the median qCS was 49% (IQR 25%-78%). Longer time to CTA was not associated with the log-transformed qCS (adjusted β per 30 minutes, 0.002, 95% CI -0.006 to 0.011). Both a higher qCS (adjusted common odds ratio [acOR] per 10% increase: 1.06, 95% CI 1.03-1.09) and shorter time to recanalization (acOR per 30 minutes: 1.17, 95% CI 1.13-1.22) were independently associated with a shift toward better functional outcome. The qCS did not modify the relation between time to recanalization and functional outcome ( DISCUSSION: In the first 6.5 hours of ischemic stroke caused by carotid terminus or M1 occlusion, the collateral status is unaffected by time to imaging, and the benefit of a shorter time to recanalization is independent of baseline collateral status.

Indexed as

Brain IschemiaEndovascular ProceduresIschemic StrokeStrokeCerebral AngiographyCollateral CirculationComputed Tomography AngiographyHumansOdds RatioTreatment Outcome

Identifiers

PMID35918164
PMCPMC9559948

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.