Evidence map›Paper›PMID 35918162›Full record

Observational studyNeurology2022

Low Values for Blood Pressure, BMI, and Non-HDL Cholesterol and the Risk of Late-Life Dementia.

Melina G H E den Brok, Esmé Eggink, Marieke P Hoevenaar-Blom, Willem A van Gool, Eric P Moll van Charante, Edo Richard, Jan Willem van Dalen

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Melina G H E den BrokFrom the Department of Neurology (M.G.H.E.B., E.R., J.W.D.), Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen; Department of Neurology (M.G.H.E.B., J.W.D.), Amsterdam University Medical Center, location AMC; Departments of General Practice (E.E.), and Public and Occupational Health (M.P.H.-B., W.A.G., E.P.M.C., E.R.), Amsterdam Public Health Research Institute, Amsterdam University Medical Center, location AMC, the Netherlands. melina.denbrok@radboudumc.nl.
Esmé EgginkFrom the Department of Neurology (M.G.H.E.B., E.R., J.W.D.), Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen; Department of Neurology (M.G.H.E.B., J.W.D.), Amsterdam University Medical Center, location AMC; Departments of General Practice (E.E.), and Public and Occupational Health (M.P.H.-B., W.A.G., E.P.M.C., E.R.), Amsterdam Public Health Research Institute, Amsterdam University Medical Center, location AMC, the Netherlands.
Marieke P Hoevenaar-BlomFrom the Department of Neurology (M.G.H.E.B., E.R., J.W.D.), Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen; Department of Neurology (M.G.H.E.B., J.W.D.), Amsterdam University Medical Center, location AMC; Departments of General Practice (E.E.), and Public and Occupational Health (M.P.H.-B., W.A.G., E.P.M.C., E.R.), Amsterdam Public Health Research Institute, Amsterdam University Medical Center, location AMC, the Netherlands.
Willem A van GoolFrom the Department of Neurology (M.G.H.E.B., E.R., J.W.D.), Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen; Department of Neurology (M.G.H.E.B., J.W.D.), Amsterdam University Medical Center, location AMC; Departments of General Practice (E.E.), and Public and Occupational Health (M.P.H.-B., W.A.G., E.P.M.C., E.R.), Amsterdam Public Health Research Institute, Amsterdam University Medical Center, location AMC, the Netherlands.
Eric P Moll van CharanteFrom the Department of Neurology (M.G.H.E.B., E.R., J.W.D.), Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen; Department of Neurology (M.G.H.E.B., J.W.D.), Amsterdam University Medical Center, location AMC; Departments of General Practice (E.E.), and Public and Occupational Health (M.P.H.-B., W.A.G., E.P.M.C., E.R.), Amsterdam Public Health Research Institute, Amsterdam University Medical Center, location AMC, the Netherlands.
Edo RichardFrom the Department of Neurology (M.G.H.E.B., E.R., J.W.D.), Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen; Department of Neurology (M.G.H.E.B., J.W.D.), Amsterdam University Medical Center, location AMC; Departments of General Practice (E.E.), and Public and Occupational Health (M.P.H.-B., W.A.G., E.P.M.C., E.R.), Amsterdam Public Health Research Institute, Amsterdam University Medical Center, location AMC, the Netherlands.
Jan Willem van DalenFrom the Department of Neurology (M.G.H.E.B., E.R., J.W.D.), Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen; Department of Neurology (M.G.H.E.B., J.W.D.), Amsterdam University Medical Center, location AMC; Departments of General Practice (E.E.), and Public and Occupational Health (M.P.H.-B., W.A.G., E.P.M.C., E.R.), Amsterdam Public Health Research Institute, Amsterdam University Medical Center, location AMC, the Netherlands.
Radboud University Medical Center · NLAmsterdam University Medical Centers · NLRadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesLow values of blood pressure, body mass index (BMI), and non-high-density lipoprotein (HDL) cholesterol have all been associated with increased dementia risk in late life, but whether these risk factors have an additive effect is unknown. This study assessed whether a combination of late-life low values for systolic blood pressure (SBP), BMI, and non-HDL cholesterol is associated with a higher dementia risk than individual low values of these risk factors.

methodsThis is a post hoc analysis based on an observational extended follow-up of the Prevention of Dementia by Intensive Vascular Care (preDIVA) trial, including community-dwelling individuals, aged 70-78 years and free from dementia at baseline. We assessed the association of baseline low values of SBP, BMI, and non-HDL cholesterol with incident dementia using Cox regression analyses. First, we assessed the respective associations between quintiles of each risk factor and dementia. Second, we explored whether combinations of low values for cardiovascular risk factors increased dementia risk, adjusted for interaction and potential confounders.

resultsDuring a median follow-up of 10.3 years (interquartile range 7.0-10.9 years), 308 of 2,789 participants (11.0%) developed dementia, and 793 (28.4%) died. For all risk factors, the lowest quintile was associated with the highest adjusted risk for dementia. Individuals with 1, 2, and 3 low values had adjusted HRs of 1.18 (95% CI 0.93-1.51), 1.28 (95% CI 0.85-1.93), and 4.02 (95% CI 2.04-7.93), respectively, compared with those without any low values. This effect was not driven by any specific combination of 2 risk factors and could not be explained by competing risk of death. DISCUSSION: Older individuals with low values for SBP, BMI, or non-HDL cholesterol have a higher dementia risk compared with individuals without any low values. Dementia risk was substantially higher in individuals with low values for all 3 risk factors than expected based on a dose-response relationship. This suggests the presence of an overarching phenomenon that involves multiple risk factors simultaneously, rather than resulting from independent effects of each individual risk factor. TRIAL REGISTRATION INFORMATION: ISRCTN registry preDIVA: ISRCTN29711771. Date of study submission to ISRCTN registry: February 14, 2006. Recruitment start date: January 1, 2006. doi.org/10.1186/ISRCTN29711771.

Indexed as

CholesterolDementiaAgedBlood PressureBody Mass IndexCholesterol, HDLHumansLipoproteinsRisk FactorsCholesterolCholesterol, HDLLipoproteins

Identifiers

PMID35918162
PMCPMC9559949
OpenAlexW4289522552

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.