Evidence map›Paper›PMID 35918153›Full record

ArticleNeurology2022

Association of Cerebrovascular and Alzheimer Disease Biomarkers With Cholinergic White Matter Degeneration in Cognitively Unimpaired Individuals.

Nira Cedres, Daniel Ferreira, Milan Nemy, Alejandra Machado, Joana B Pereira, Sara Shams, Lars-Olof Wahlund, Anna Zettergren, Olga Stepankova, Lenka Vyslouzilova and 9 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Post mortem MRI of cholinergic white matter pathways across neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
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  7. Brain cholinergic terminal density utilizing [Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  8. Article
  9. Article
  10. Review
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  12. Article
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Nira CedresFrom the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.ORCID 0000-0002-1850-6451
Daniel FerreiraFrom the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK. daniel.ferreira.padilla@ki.se.ORCID 0000-0001-9522-4338
Milan NemyFrom the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Alejandra MachadoFrom the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Joana B PereiraFrom the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Sara ShamsFrom the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Lars-Olof WahlundFrom the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Anna ZettergrenFrom the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Olga StepankovaFrom the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Lenka VyslouzilovaFrom the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Maria EriksdotterFrom the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Stefan TeipelFrom the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Michel J GrotheFrom the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Kaj BlennowFrom the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.ORCID 0000-0002-1890-4193
Henrik ZetterbergFrom the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.ORCID 0000-0002-4671-6763
Michael SchöllFrom the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.ORCID 0000-0001-7800-1781
Silke KernFrom the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Ingmar SkoogFrom the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Eric WestmanFrom the Division of Clinical Geriatrics (N.C., D.F., A.M., J.B.P., S.S., L.-O.W., M.E., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, and the Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; Department of Psychology (N.C.), Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Sweden; Department of Radiology (D.F.), Mayo Clinic, Rochester, MN; Department of Cybernetics (M.N.), Faculty of Electrical Engineering and Czech Institute of Informatics (M.N., O.S., L.V.), Robotics, and Cybernetics, Czech Technical University, Prague, Czech Republic; Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Lund University, Malmö; Department of Psychiatry Cognition and Old Age Psychiatry, (A.Z., S.K., I.S.), Clinical Neurochemistry Laboratory (K.B., H.Z.), and Department of Clinical Physiology (M.S.), Sahlgrenska University Hospital, Gothenburg; Neuropsychiatric Epidemiology Unit (A.Z., K.B., H.Z., S.K., I.S.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg; Theme Inflammation and Aging (M.E.), Karolinska University Hospital, Huddinge, Sweden; Clinical Dementia Research Section (S.T.), Department of Psychosomatic Medicine, University Medicine Rostock; German Center for Neurodegenerative Diseases (DZNE) (S.T., M.J.G.), Rostock, Germany; Unidad de Trastornos del Movimiento (M.J.G.), Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London; Dementia Research Institute at UCL (H.Z.), London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Wallenberg Centre for Molecular and Translational Medicine (M.S.) and Department of Psychiatry and Neurochemistry (M.S.), Institute of Physiology and Neuroscience, University of Gothenburg, Sweden; Dementia Research Centre (M.S.), Institute of Neurology, University College London; and Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.ORCID 0000-0002-3115-2977
Karolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesSeveral pathologic processes might contribute to the degeneration of the cholinergic system in aging. We aimed to determine the contribution of amyloid, tau, and cerebrovascular biomarkers toward the degeneration of cholinergic white matter (WM) projections in cognitively unimpaired individuals.

methodsThe contribution of amyloid and tau pathology was assessed through CSF levels of the Aβ

resultsWe included 203 cognitively unimpaired individuals from the H70 Gothenburg Birth Cohort Studies (all individuals aged 70 years, 51% female). WM lesion burden was the most important contributor to the degeneration of both cholinergic pathways (increase in mean square error [IncMSE] = 98.8% in the external capsule pathway and IncMSE = 93.3% in the cingulum pathway). Levels of Aβ DISCUSSION: In cognitively unimpaired older individuals, WMLs play a central role in the degeneration of cholinergic pathways. Our findings highlight the importance of WM lesion burden in the elderly population, which should be considered in the development of prevention programs for neurodegeneration and cognitive impairment.

Indexed as

Alzheimer DiseaseAmyloidosisWhite MatterAgedAmyloidAmyloid beta-PeptidesAmyloidogenic ProteinsApolipoprotein E4BiomarkersCholinergic AgentsDiffusion Tensor ImagingFemaleHumansMaletau ProteinsAmyloidAmyloid beta-PeptidesAmyloidogenic ProteinsApolipoprotein E4BiomarkersCholinergic Agentstau Proteins

Identifiers

PMID35918153
PMCPMC9559946
OpenAlexW4289520024

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