ArticleDevelopmental cell2022
N
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In one paragraph
Article in Developmental cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
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- Gasdermin C links nutrient and immune signaling to protist-induced type 2 immunity and intestinal repair.bioRxiv : the preprint server for biology · 2025Article
- Causal Relationship Between Mitochondrial Characteristics and Inflammatory Bowel Disease and Its Subtypes: Evidence for Mendelian Randomization.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
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- Caspase-6/Gasdermin C-Mediated Tumor Cell Pyroptosis Promotes Colorectal Cancer Progression Through CXCL2-Dependent Recruitment of Myeloid-Derived Suppressor Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Epigenetics in neonatal necrotizing enterocolitis: current understanding and the potential involvement of m6A modification.Frontiers in pediatrics · 2025Review
- Biological and pharmacological roles of pyroptosis in pulmonary inflammation and fibrosis: recent advances and future directions.Cell communication and signaling : CCS · 2024Review
- Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation.Developmental cell · 2024Article
- METTL3 restricts RIPK1-dependent cell death via the ATF3-cFLIP axis in the intestinal epithelium.Cell regeneration (London, England) · 2024Article
- Nurturing gut health: role of m6A RNA methylation in upholding the intestinal barrier.Cell death discovery · 2024Review
- To die or not to die: Gasdermins in intestinal health and disease.Seminars in immunology · 2024Review
- METTL14 Regulates the m6A Modification of TRAF6 to Suppress Mitochondrial Dysfunction and Ferroptosis in Dopaminergic Neurons via the cGAS-STING Pathway.Current molecular medicine · 2024Article
- Intestinal transit-amplifying cells require METTL3 for growth factor signaling and cell survival.JCI insight · 2023Article
- Phase separation of BuGZ regulates gut regeneration and aging through interaction with mNature communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 1 institution in 1 country.
Jie DuDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA; Department of Oral Medicine, School and Hospital of Stomatology, Shanxi Medical University, Taiyuan, Shanxi, China.
Rajesh SarkarDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA.
Yan LiCenter for Research Informatics, The University of Chicago, Chicago, IL, USA.
Lei HeDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA.
Wenjun KangCenter for Research Informatics, The University of Chicago, Chicago, IL, USA.
Wang LiaoDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA; Department of Cardiology, Hainan General Hospital, Hainan Clinical Research Institute, Haikou, Hainan, China.
Weicheng LiuDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA.
Tivoli NguyenDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA.
Linda ZhangDepartments of Chemistry, Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.
Zifeng DengDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA.
Urszula DoughertyDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA.
Sonia S KupferDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA.
Mengjie ChenDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA; Center for Research Informatics, The University of Chicago, Chicago, IL, USA.
Joel PekowDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA.
Marc BissonnetteDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA.
Chuan HeDepartments of Chemistry, Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA.
Yan Chun LiDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA. Electronic address: cyan@medicine.bsd.uchicago.edu.
University of Chicago · US
Funding
The Institute for Translational MedicineUL1TR002389 · NCATS · UNIVERSITY OF CHICAGO · PI Joshua J Jacobs, DAVID O MELTZER · 2017 to 2026
$71.6MTranscriptome-wide base-resolution sequencing of pseudouridine in human normal and AD brain tissues-CEGS Admin supplement 2020-2021RM1HG008935 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2016 to 2025
$24.4MFITting noninvasive testing into Lynch syndrome colorectal cancer surveillance: a multicenter, prospective trialR01CA287257 · NCI · UNIVERSITY OF CHICAGO · PI Fay Kastrinos, Sonia Kupfer · 2024 to 2026
$3.4MRoles of m6A mRNA Methylation in Innate ImmunityR01AI151162 · NIAID · UNIVERSITY OF CHICAGO · PI LI, YAN CHUN · 2020 to 2024
$2.0MColonic responses to vitamin D and aspirin in African- and European-AmericansR01CA220329 · NCI · UNIVERSITY OF CHICAGO · PI KUPFER, SONIA · 2018 to 2022
$1.9MMacrophage m6A mRNA Methylation in SepsisR21AI140152 · NIAID · UNIVERSITY OF CHICAGO · PI LI, YAN CHUN · 2018 to 2019
$446kNCATS NIH HHS UL1 TR002389NCI NIH HHS R01 CA220329NCI NIH HHS R01 CA287257NHGRI NIH HHS RM1 HG008935NIAID NIH HHS R01 AI151162NIAID NIH HHS R21 AI140152
Abstract
Gut epithelial morphogenesis is maintained by intestinal stem cells. Here, we report that depletion of N
Indexed as
Receptors, G-Protein-CoupledStem CellsAnimalsBiomarkers, TumorCell SurvivalColonDNA-Binding ProteinsGasderminsHumansMiceMorphogenesisOrganoidsPore Forming Cytotoxic ProteinsBiomarkers, TumorDNA-Binding ProteinsGasderminsGSDMC protein, humanGsdmc protein, mouseLGR5 protein, humanLgr5 protein, mousePore Forming Cytotoxic ProteinsReceptors, G-Protein-CoupledApoptosisCluColonic epitheliumGsdmCIntestinal stem cellLgr5m(6)AMettl14Mitochondria
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.