Evidence map›Paper›PMID 35917466›Full record

ArticleCirculation. Arrhythmia and electrophysiology2022

Microdystrophin Therapy Rescues Impaired Na Currents in Cardiac Purkinje Fibers From Dystrophin-Deficient Mdx Mice.

Janine Ebner, Xiufang Pan, Yongping Yue, Spyridon Sideromenos, Jessica Marksteiner, Xaver Koenig, Karlheinz Hilber, Dongsheng Duan

Abstract readLetter
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac NaAmerican journal of physiology. Heart and circulatory physiology · 2025
    Article
  3. Conduction defects and arrhythmias inFrontiers in physiology · 2025
    Article
  4. Article
  5. Empagliflozin treatment rescues abnormally reduced NaAmerican journal of physiology. Heart and circulatory physiology · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Janine Ebner *Department of Neurophysiology & Neuropharmacology, Center for Physiology & Pharmacology, Medical University of Vienna, Vienna, Austria (J.E., S.S., J.M., X.K., K.H.).
Xiufang Pan *Department of Molecular Microbiology & Immunology (X.P., Y.Y., D.D.).ORCID 0000-0002-2594-5911
Yongping YueDepartment of Molecular Microbiology & Immunology (X.P., Y.Y., D.D.).ORCID 0000-0002-1640-2106
Spyridon SideromenosDepartment of Neurophysiology & Neuropharmacology, Center for Physiology & Pharmacology, Medical University of Vienna, Vienna, Austria (J.E., S.S., J.M., X.K., K.H.).
Jessica MarksteinerDepartment of Neurophysiology & Neuropharmacology, Center for Physiology & Pharmacology, Medical University of Vienna, Vienna, Austria (J.E., S.S., J.M., X.K., K.H.).
Xaver KoenigDepartment of Neurophysiology & Neuropharmacology, Center for Physiology & Pharmacology, Medical University of Vienna, Vienna, Austria (J.E., S.S., J.M., X.K., K.H.).ORCID 0000-0002-2423-4966
Karlheinz HilberDepartment of Neurophysiology & Neuropharmacology, Center for Physiology & Pharmacology, Medical University of Vienna, Vienna, Austria (J.E., S.S., J.M., X.K., K.H.).ORCID 0000-0002-3033-0874
Dongsheng DuanDepartment of Molecular Microbiology & Immunology (X.P., Y.Y., D.D.).ORCID 0000-0003-4109-1132

Funding

Whole body single AAV microgene therapy in canine DMDR01NS090634 · NINDS · UNIVERSITY OF MISSOURI-COLUMBIA · PI Dongsheng Duan · 2015 to 2026
$4.2M
Austrian Science Fund FWF P 30234NINDS NIH HHS R01 NS090634
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DystrophinMuscular Dystrophy, DuchenneAnimalsMiceMice, Inbred C57BLMice, Inbred mdxPurkinje FibersSodiumDystrophinSodiumarrhythmia, cardiacdystrophinmicemuscular dystrophy, Duchennemyocytes, cardiac

Identifiers

PMID35917466
PMCPMC9396648

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.