Evidence map›Paper›PMID 35917107›Full record

ArticleBritish journal of haematology2022

United we stand: Double targeting of CD79B and CD20 in diffuse large B-cell lymphoma.

Chiara Tarantelli, Francesco Bertoni

Open access · hybridAbstract read
In one paragraph

Article in British journal of haematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Chiara TarantelliFaculty of Biomedical Sciences, Institute of Oncology Research, Bellinzona, Switzerland.
Francesco BertoniFaculty of Biomedical Sciences, Institute of Oncology Research, Bellinzona, Switzerland.
Institute of Oncology Research · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polatuzumab vedotin is antibody-drug conjugate (ADC) targeting CD79B approved for the treatment of patients with relapsed/refractory diffuse large B-cell lymphoma when given in combination with bendamustine and rituximab. The report by Kawasaki et al. provide hints on what might be happening in lymphoma cells exposed to polatuzumab vedotin and to rituximab and on potential mechanism of resistance to the ADC. Commentary on: Kawasaki et al. The molecular rationale for the combination of polatuzumab vedotin plus rituximab in diffuse large B-cell lymphoma. Br J Haematol 2022;199:245-255.

Indexed as

ImmunoconjugatesLymphoma, Large B-Cell, DiffuseAntigens, CD20Antineoplastic Combined Chemotherapy ProtocolsBendamustine HydrochlorideCD79 AntigensHumansRituximabAntigens, CD20Bendamustine HydrochlorideCD79 AntigensCD79B protein, humanImmunoconjugatesRituximabantibody-drug conjugatelymphomaMMAEpolatuzumab vedotinresistancerituximab

Identifiers

PMID35917107
PMCPMC9804191
OpenAlexW4289518187

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.