ArticleRadiology2022
Sex Differences in Airways at Chest CT: Results from the COPDGene Cohort.
Open access · greenAbstract readMulticenter Study
In one paragraph
Article in Radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
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- CT image-based machine learning models for predicting blood eosinophil levels in acute exacerbation of chronic obstructive pulmonary disease.BMC pulmonary medicine · 2026Article
- Sex and Gender in Chronic Obstructive Pulmonary Disease: Does It Matter?Journal of personalized medicine · 2026Review
- Delivery of siRNA and Chloroquine Through an Aspherical, Nanostructured Microparticle for Passive Targeting of Alveolar Macrophages and Inhibition of Local TNF-α Secretion.Pharmaceutics · 2026Article
- Sex differences in the work of breathing during exercise are independent of forced vital capacity in healthy adults.Experimental physiology · 2025Article
- An Examination of Sex Differences and Cigarette Smoking as Predictors of COPD Prevalence and Incidence in Older US Adults.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Normative values for lung, bronchial sizes, and bronchus-artery ratios in chest CT scans: from infancy into young adulthood.European radiology · 2025Article
- Gender, tobacco and chronic obstructive pulmonary disease: analysis of the 2020 National Health Interview Survey.BMJ open respiratory research · 2025Article
- Sex Differences in Chronic Obstructive Pulmonary Disease: Implications for Pathogenesis, Diagnosis, and Treatment.International journal of molecular sciences · 2025Review
- Quantitative CT and COPD: cluster analysis reveals five distinct subtypes with varying exacerbation risks.BMC pulmonary medicine · 2025Article
- Case Report: Emergency management of difficult airway in a thyroid cancer patient with undiagnosed tracheal diverticulum preoperatively and literature review.Frontiers in medicine · 2025Article
- Differences between women and men in prolonged weaning.Respiratory research · 2024Article
- Increased adiposity-to-muscle ratio and severity of sinusitis affect quality of life in asthma: Computed tomographic analysis.The journal of allergy and clinical immunology. Global · 2024Article
- Gender differences in association between expiratory dynamic airway collapse and severity of obstructive sleep apnea.European radiology · 2024Article
- Unadjusted Lower Limit of Normal for Airflow Obstruction.American journal of respiratory and critical care medicine · 2024Article
- Chronic respiratory symptoms following deployment-related occupational and environmental exposures among US veterans.Occupational and environmental medicine · 2024Article
- Reply to Neder, to OgataAmerican journal of respiratory and critical care medicine · 2024Article
- Dysanapsis is differentially related to lung function trajectories with distinct structural and functional patterns in COPD and variable risk for adverse outcomes.EClinicalMedicine · 2024Article
- [Epidemiology and hospitalization costs analysis of female inpatients with acute exacerbation of chronic obstructive pulmonary disease in Beijing from 2013 to 2020].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- Cigarette smoking and disproportionate changes of thoracic skeletal muscles in low-dose chest computed tomography.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Surya P BhattFrom the UAB Lung Imaging Lab (S.P.B., S.B., A.N.), UAB Lung Health Center (S.P.B., S.B.), Division of Pulmonary, Allergy and Critical Care Medicine (S.P.B., S.B.), Department of Electrical and Computer Engineering (A.N.), and Division of Preventive Medicine (Y.I.K.), University of Alabama at Birmingham, 1720 2nd Ave S, THT 422, Birmingham, AL 35294; Roy J. Carver Department of Biomedical Engineering (J.M.R.) and Department of Radiology (E.A.H., A.M.), University of Iowa, Iowa City, Iowa; Departments of Biostatistics and Bioinformatics (C.G.W.), Radiology (S.M.H.), and Medicine (E.A.R.), National Jewish Health, Denver, Colo; and Channing Division of Network Medicine and the Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (D.L.D.).ORCID 0000-0002-8418-4497
Sandeep BodduluriFrom the UAB Lung Imaging Lab (S.P.B., S.B., A.N.), UAB Lung Health Center (S.P.B., S.B.), Division of Pulmonary, Allergy and Critical Care Medicine (S.P.B., S.B.), Department of Electrical and Computer Engineering (A.N.), and Division of Preventive Medicine (Y.I.K.), University of Alabama at Birmingham, 1720 2nd Ave S, THT 422, Birmingham, AL 35294; Roy J. Carver Department of Biomedical Engineering (J.M.R.) and Department of Radiology (E.A.H., A.M.), University of Iowa, Iowa City, Iowa; Departments of Biostatistics and Bioinformatics (C.G.W.), Radiology (S.M.H.), and Medicine (E.A.R.), National Jewish Health, Denver, Colo; and Channing Division of Network Medicine and the Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (D.L.D.).
Arie NakhmaniFrom the UAB Lung Imaging Lab (S.P.B., S.B., A.N.), UAB Lung Health Center (S.P.B., S.B.), Division of Pulmonary, Allergy and Critical Care Medicine (S.P.B., S.B.), Department of Electrical and Computer Engineering (A.N.), and Division of Preventive Medicine (Y.I.K.), University of Alabama at Birmingham, 1720 2nd Ave S, THT 422, Birmingham, AL 35294; Roy J. Carver Department of Biomedical Engineering (J.M.R.) and Department of Radiology (E.A.H., A.M.), University of Iowa, Iowa City, Iowa; Departments of Biostatistics and Bioinformatics (C.G.W.), Radiology (S.M.H.), and Medicine (E.A.R.), National Jewish Health, Denver, Colo; and Channing Division of Network Medicine and the Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (D.L.D.).ORCID 0000-0002-0987-4834
Young-Il KimFrom the UAB Lung Imaging Lab (S.P.B., S.B., A.N.), UAB Lung Health Center (S.P.B., S.B.), Division of Pulmonary, Allergy and Critical Care Medicine (S.P.B., S.B.), Department of Electrical and Computer Engineering (A.N.), and Division of Preventive Medicine (Y.I.K.), University of Alabama at Birmingham, 1720 2nd Ave S, THT 422, Birmingham, AL 35294; Roy J. Carver Department of Biomedical Engineering (J.M.R.) and Department of Radiology (E.A.H., A.M.), University of Iowa, Iowa City, Iowa; Departments of Biostatistics and Bioinformatics (C.G.W.), Radiology (S.M.H.), and Medicine (E.A.R.), National Jewish Health, Denver, Colo; and Channing Division of Network Medicine and the Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (D.L.D.).ORCID 0000-0001-6806-4551
Joseph M ReinhardtFrom the UAB Lung Imaging Lab (S.P.B., S.B., A.N.), UAB Lung Health Center (S.P.B., S.B.), Division of Pulmonary, Allergy and Critical Care Medicine (S.P.B., S.B.), Department of Electrical and Computer Engineering (A.N.), and Division of Preventive Medicine (Y.I.K.), University of Alabama at Birmingham, 1720 2nd Ave S, THT 422, Birmingham, AL 35294; Roy J. Carver Department of Biomedical Engineering (J.M.R.) and Department of Radiology (E.A.H., A.M.), University of Iowa, Iowa City, Iowa; Departments of Biostatistics and Bioinformatics (C.G.W.), Radiology (S.M.H.), and Medicine (E.A.R.), National Jewish Health, Denver, Colo; and Channing Division of Network Medicine and the Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (D.L.D.).ORCID 0000-0003-3526-3591
Eric A HoffmanFrom the UAB Lung Imaging Lab (S.P.B., S.B., A.N.), UAB Lung Health Center (S.P.B., S.B.), Division of Pulmonary, Allergy and Critical Care Medicine (S.P.B., S.B.), Department of Electrical and Computer Engineering (A.N.), and Division of Preventive Medicine (Y.I.K.), University of Alabama at Birmingham, 1720 2nd Ave S, THT 422, Birmingham, AL 35294; Roy J. Carver Department of Biomedical Engineering (J.M.R.) and Department of Radiology (E.A.H., A.M.), University of Iowa, Iowa City, Iowa; Departments of Biostatistics and Bioinformatics (C.G.W.), Radiology (S.M.H.), and Medicine (E.A.R.), National Jewish Health, Denver, Colo; and Channing Division of Network Medicine and the Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (D.L.D.).ORCID 0000-0001-8456-9437
Amin MotahariFrom the UAB Lung Imaging Lab (S.P.B., S.B., A.N.), UAB Lung Health Center (S.P.B., S.B.), Division of Pulmonary, Allergy and Critical Care Medicine (S.P.B., S.B.), Department of Electrical and Computer Engineering (A.N.), and Division of Preventive Medicine (Y.I.K.), University of Alabama at Birmingham, 1720 2nd Ave S, THT 422, Birmingham, AL 35294; Roy J. Carver Department of Biomedical Engineering (J.M.R.) and Department of Radiology (E.A.H., A.M.), University of Iowa, Iowa City, Iowa; Departments of Biostatistics and Bioinformatics (C.G.W.), Radiology (S.M.H.), and Medicine (E.A.R.), National Jewish Health, Denver, Colo; and Channing Division of Network Medicine and the Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (D.L.D.).
Carla G WilsonFrom the UAB Lung Imaging Lab (S.P.B., S.B., A.N.), UAB Lung Health Center (S.P.B., S.B.), Division of Pulmonary, Allergy and Critical Care Medicine (S.P.B., S.B.), Department of Electrical and Computer Engineering (A.N.), and Division of Preventive Medicine (Y.I.K.), University of Alabama at Birmingham, 1720 2nd Ave S, THT 422, Birmingham, AL 35294; Roy J. Carver Department of Biomedical Engineering (J.M.R.) and Department of Radiology (E.A.H., A.M.), University of Iowa, Iowa City, Iowa; Departments of Biostatistics and Bioinformatics (C.G.W.), Radiology (S.M.H.), and Medicine (E.A.R.), National Jewish Health, Denver, Colo; and Channing Division of Network Medicine and the Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (D.L.D.).ORCID 0000-0002-1076-5205
Stephen M HumphriesFrom the UAB Lung Imaging Lab (S.P.B., S.B., A.N.), UAB Lung Health Center (S.P.B., S.B.), Division of Pulmonary, Allergy and Critical Care Medicine (S.P.B., S.B.), Department of Electrical and Computer Engineering (A.N.), and Division of Preventive Medicine (Y.I.K.), University of Alabama at Birmingham, 1720 2nd Ave S, THT 422, Birmingham, AL 35294; Roy J. Carver Department of Biomedical Engineering (J.M.R.) and Department of Radiology (E.A.H., A.M.), University of Iowa, Iowa City, Iowa; Departments of Biostatistics and Bioinformatics (C.G.W.), Radiology (S.M.H.), and Medicine (E.A.R.), National Jewish Health, Denver, Colo; and Channing Division of Network Medicine and the Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (D.L.D.).ORCID 0000-0002-5113-4530
Elizabeth A ReganFrom the UAB Lung Imaging Lab (S.P.B., S.B., A.N.), UAB Lung Health Center (S.P.B., S.B.), Division of Pulmonary, Allergy and Critical Care Medicine (S.P.B., S.B.), Department of Electrical and Computer Engineering (A.N.), and Division of Preventive Medicine (Y.I.K.), University of Alabama at Birmingham, 1720 2nd Ave S, THT 422, Birmingham, AL 35294; Roy J. Carver Department of Biomedical Engineering (J.M.R.) and Department of Radiology (E.A.H., A.M.), University of Iowa, Iowa City, Iowa; Departments of Biostatistics and Bioinformatics (C.G.W.), Radiology (S.M.H.), and Medicine (E.A.R.), National Jewish Health, Denver, Colo; and Channing Division of Network Medicine and the Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (D.L.D.).ORCID 0000-0003-0624-9184
Dawn L DeMeoFrom the UAB Lung Imaging Lab (S.P.B., S.B., A.N.), UAB Lung Health Center (S.P.B., S.B.), Division of Pulmonary, Allergy and Critical Care Medicine (S.P.B., S.B.), Department of Electrical and Computer Engineering (A.N.), and Division of Preventive Medicine (Y.I.K.), University of Alabama at Birmingham, 1720 2nd Ave S, THT 422, Birmingham, AL 35294; Roy J. Carver Department of Biomedical Engineering (J.M.R.) and Department of Radiology (E.A.H., A.M.), University of Iowa, Iowa City, Iowa; Departments of Biostatistics and Bioinformatics (C.G.W.), Radiology (S.M.H.), and Medicine (E.A.R.), National Jewish Health, Denver, Colo; and Channing Division of Network Medicine and the Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (D.L.D.).
University of Alabama at Birmingham · USNational Jewish Health · USUniversity of Iowa · USBrigham and Women's Hospital · US
Funding
Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9MStructural Determinants of Disease Progression in COPDR01HL151421 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BHATT, SURYA P., NAKHMANI, ARIE · 2020 to 2024
$2.6MLung Biomechanics and Disease Progression in SPIROMICSR01HL142625 · NHLBI · UNIVERSITY OF IOWA · PI REINHARDT, JOSEPH M · 2018 to 2021
$2.2MNetworks Tools to Understand Sex- and Gender-Specific Drivers of DiseaseR01HG011393 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMEO, DAWN L, QUACKENBUSH, JOHN · 2021 to 2024
$2.1M1/2 Video Telehealth Pulmonary Rehabilitation to Reduce Hospital Readmission in Chronic Obstructive Pulmonary Disease (Tele-COPD)UG3HL155806 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BHATT, SURYA P. · 2021 to 2021
$1.5MDiastolic Dysfunction and Pauci-inflammatory Acute Exacerbations of Chronic Obstructive Pulmonary DiseaseK23HL133438 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BHATT, SURYA P. · 2016 to 2020
$921kDeep Learning and Fluid Dynamics Based Phenotyping of Expiratory Central Airway CollapseR21EB027891 · NIBIB · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BHATT, SURYA P., RAGHAV, VRISHANK · 2019 to 2021
$599kNHGRI NIH HHS R01 HG011393NHLBI NIH HHS K23 HL133438NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL142625NHLBI NIH HHS R01 HL151421NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NIBIB NIH HHS R21 EB027891
Abstract
Background The prevalence of chronic obstructive pulmonary disease (COPD) in women is fast approaching that in men, and women experience greater symptom burden. Although sex differences in emphysema have been reported, differences in airways have not been systematically characterized. Purpose To evaluate whether structural differences in airways may underlie some of the sex differences in COPD prevalence and clinical outcomes. Materials and Methods In a secondary analyses of a multicenter study of never-, current-, and former-smokers enrolled from January 2008 to June 2011 and followed up longitudinally until November 2020, airway disease on CT images was quantified using seven metrics: airway wall thickness, wall area percent, and square root of the wall thickness of a hypothetical airway with internal perimeter of 10 mm (referred to as Pi10) for airway wall; and lumen diameter, airway volume, total airway count, and airway fractal dimension for airway lumen. Least-squares mean values for each airway metric were calculated and adjusted for age, height, ethnicity, body mass index, pack-years of smoking, current smoking status, total lung capacity, display field of view, and scanner type. In ever-smokers, associations were tested between each airway metric and postbronchodilator forced expiratory volume in 1 second (FEV
Indexed as
Pulmonary Disease, Chronic ObstructiveQuality of LifeDyspneaFemaleForced Expiratory VolumeHumansLungMaleSex CharacteristicsTomography, X-Ray Computed
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