Evidence map›Paper›PMID 35916669›Full record

Trial reportGut microbes

Improved gut microbiome recovery following drug therapy is linked to abundance and replication of probiotic strains.

Jamie FitzGerald, Shriram Patel, Julia Eckenberger, Eric Guillemard, Patrick Veiga, Florent Schäfer, Jens Walter, Marcus J Claesson, Muriel Derrien

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Evaluation of efficacy and safety ofFrontiers in immunology · 2024
    Trial
  4. Review
  5. Review
  6. Review
  7. Beyond Antibiotics: Alternative Strategies TargetingExpert reviews in molecular medicine · 2026
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Antibiotic-perturbed microbiota and the role of probiotics.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  16. TargetingNutrients · 2025
    Review
  17. Article
  18. Article
  19. Review
  20. ExploringMicrobiome research reports · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Jamie FitzGeraldSchool of Microbiology, University College Cork, Cork, Ireland.ORCID 0000-0003-1060-816X
Shriram PatelSchool of Microbiology, University College Cork, Cork, Ireland.ORCID 0000-0002-5062-0289
Julia EckenbergerSchool of Microbiology, University College Cork, Cork, Ireland.ORCID 0000-0003-4781-0660
Eric GuillemardAdvanced Health & Science, Danone Nutricia Research, Palaiseau, France.ORCID 0000-0001-5126-0433
Patrick VeigaAdvanced Health & Science, Danone Nutricia Research, Palaiseau, France.ORCID 0000-0001-6318-8547
Florent SchäferAdvanced Health & Science, Danone Nutricia Research, Palaiseau, France.ORCID 0000-0001-6816-5731
Jens WalterSchool of Microbiology, University College Cork, Cork, Ireland.ORCID 0000-0003-1754-172X
Marcus J ClaessonSchool of Microbiology, University College Cork, Cork, Ireland.ORCID 0000-0002-5712-0623
Muriel DerrienAdvanced Health & Science, Danone Nutricia Research, Palaiseau, France.ORCID 0000-0001-8841-9153
University College Cork · IEDanone (France) · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Probiotics have been used for decades to alleviate the negative side-effects of oral antibiotics, but our mechanistic understanding on how they work is so far incomplete. Here, we performed a metagenomic analysis of the fecal microbiota in participants who underwent a 14-d

Indexed as

Cultured Milk ProductsGastrointestinal MicrobiomeProbioticsAnti-Bacterial AgentsFecesHumansAnti-Bacterial AgentsAntibioticsfermented milk productgut microbiome recoveryL. paracasei CNCM I-1518probioticsreplication

Identifiers

PMID35916669
PMCPMC9348039
OpenAlexW4289519288

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.