ArticleAngewandte Chemie (International ed. in English)2022
Diastereoselective, Catalytic Access to Cross-Aldol Products Directly from Esters and Lactones.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 13 citations in OpenAlex.
- Stereoselective, borane-catalysed synthesis ofChemical science · 2026Article
- Group 13 exchange and transborylation in catalysis.Beilstein journal of organic chemistry · 2023Review
- Diastereoselective, Catalytic Access to Cross-Aldol Products Directly from Esters and Lactones.Angewandte Chemie (International ed. in English) · 2022Article
- Boron-Catalyzed, Diastereo- and Enantioselective Allylation of Ketones with Allenes.ACS catalysis · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 4 countries.
Funding
Abstract
High oxidation-state carbonyl coupling partners including esters and lactones were reacted with enones to give aldol-type products directly using two-fold organoborane catalysis. This new retrosynthetic disconnection to aldol-type products is compatible with enolisable coupling partners, without self-condensation, and couples the high reactivity of secondary dialkylboranes with the stability of pinacolboronic esters. Excellent chemoselectivity, substrate scope (including those containing reducible functionalities and free alcohols) and diastereocontrol were achieved to access both the syn- and anti-aldol-type products. Mechanistic studies confirmed the two-fold catalytic role of the single secondary borane catalyst for boron enolate formation and formation of an aldehyde surrogate from the ester or lactone coupling partner.
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Registered trials
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