Evidence map›Paper›PMID 35916537›Full record

ReviewCurrent opinion in hematology2022

Hyperviscosity syndromes; hemorheology for physicians and the use of microfluidic devices.

Jamie O Musick, Kirby S Fibben, Wilbur A Lam

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in hematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Jamie O MusickDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Emory University School of Medicine.
Kirby S FibbenWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.
Wilbur A LamDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Emory University School of Medicine.
Children's Center · USChildren's Healthcare of Atlanta · USGeorgia Institute of Technology · US

Funding

Engineering biophysical microtechnologies for hematologic applications in health and diseaseR35HL145000 · NHLBI · EMORY UNIVERSITY · PI LAM, WILBUR A · 2019 to 2025
$5.0M
Redefining Clinical Viscosity in Sickle Cell Diseaseby Leveraging Microfluidic TechnologiesR01HL140589 · NHLBI · EMORY UNIVERSITY · PI LAM, WILBUR A, WOOD, DAVID KEVIN · 2018 to 2021
$3.0M
Research Training in Pediatric Non-Malignant HematologyT32HL139443 · NHLBI · EMORY UNIVERSITY · PI Clinton H Joiner, Shannon L. Meeks · 2018 to 2026
$2.6M
NHLBI NIH HHS R01 HL140589NHLBI NIH HHS R35 HL145000NHLBI NIH HHS T32 HL139443
6 · The paper itself

Abstract

purpose of reviewHyperviscosity syndromes can lead to significant morbidity and mortality. Existing methods to measure microcirculatory rheology are not readily available and limited in relevance and accuracy at this level. In this review, we review selected hyperviscosity syndromes and the advancement of their knowledge using microfluidic platforms. RECENT

findingsViscosity changes drastically at the microvascular level as the physical properties of the cells themselves become the major determinants of resistance to blood flow. Current, outdated viscosity measurements only quantify whole blood or serum. Changes in blood composition, cell number, or the physical properties themselves lead to increased blood viscosity. Given the significant morbidity and mortality from hyperviscosity syndromes, new biophysical tools are needed and being developed to study microvascular biophysical and hemodynamic conditions at this microvascular level to help predict those at risk and guide therapeutic treatment. SUMMARY: The use of 'lab-on-a-chip' technology continues to rise to relevance with point of care, personalized testing and medicine as customizable microfluidic platforms enable independent control of many in vivo factors and are a powerful tool to study microcirculatory hemorheology.

Indexed as

Hematologic DiseasesPhysiciansBlood ViscosityHemorheologyHumansLab-On-A-Chip DevicesMicrocirculation

Identifiers

PMID35916537
PMCPMC9547821
OpenAlexW4289450222

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.