Evidence map›Paper›PMID 35916504›Full record

ArticleLangmuir : the ACS journal of surfaces and colloids2022

Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-transcriptional Gene Regulation and Apoptosis of A549 Cells.

Nick A Alden, Julien H Arrizabalaga, Yiming Liu, Shantu Amin, Krishne Gowda, Shun Yao, Marco Archetti, Adam B Glick, Daniel J Hayes

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Langmuir : the ACS journal of surfaces and colloids, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Nick A AldenThe Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0003-1380-131X
Julien H ArrizabalagaThe Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0001-8603-4575
Yiming LiuThe Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Shantu AminPenn State Hershey Cancer Institute, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, United States.ORCID 0000-0003-2780-2567
Krishne GowdaPenn State Hershey Cancer Institute, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, United States.ORCID 0000-0002-6042-0520
Shun YaoThe Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Marco ArchettiThe Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Adam B GlickThe Huck Institute of the Life Sciences, Millennium Science Complex, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Daniel J HayesThe Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0001-9499-4111
Pennsylvania State University · US

Funding

Spatiotemporal Modulation of Osteogenesis in a 3-D Stromal/Stem Cell ModelR01DE024790 · NIDCR · PENNSYLVANIA STATE UNIVERSITY, THE · PI HAYES, DANIEL J. · 2015 to 2019
$1.7M
NIDCR NIH HHS R01 DE024790
6 · The paper itself

Abstract

In this study, we utilized selectively modified, biodegradable polymer-based polyplexes to deliver custom, exogenous miR-148b mimics to induce apoptosis in human lung cancer (A549) cells. The gene regulatory effects of the payload miRNA mimics (miR-148b-3p) were first evaluated through bioinformatic analyses to uncover specific gene targets involved in critical carcinogenic pathways. Hyperbranched poly(β amino ester) polyplexes (hPBAE) loaded with custom miR-148b mimics were then developed for targeted therapy. When evaluated

Indexed as

EstersMicroRNAsA549 CellsApoptosisCell ProliferationHumansPoly APolymersEstersMicroRNAsPoly Apoly(beta-amino ester)Polymers

Identifiers

PMID35916504
PMCPMC10496413
OpenAlexW4289443472

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.