Evidence map›Paper›PMID 35916501›Full record

ArticleApplied and environmental microbiology2022

The Proteome of Extracellular Vesicles Produced by the Human Gut Bacteria Bacteroides thetaiotaomicron

Régis Stentz, Emily Jones, Rokas Juodeikis, Udo Wegmann, Maria Guirro, Andrew J Goldson, Arlaine Brion, Catherine Booth, Padhmanand Sudhakar, Ian R Brown and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. International journal of molecular sciences · 2026
    Article
  5. [Research progress on the mechanism and potential applications of gut microbiota-derived extracellular vesicles in ischemic stroke].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Review
  6. Extracellular vesicles as indicators of environmental stress response inExtracellular vesicles and circulating nucleic acids · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. International journal of molecular sciences · 2025
    Article
  14. Review
  15. Review
  16. Loss ofMicrobiology spectrum · 2024
    Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Régis Stentz *Gut Microbes and Health Research Programme, Quadram Institute Bioscience, Norwich, United Kingdom.ORCID 0000-0003-1021-9439
Emily Jones *Gut Microbes and Health Research Programme, Quadram Institute Bioscience, Norwich, United Kingdom.
Rokas JuodeikisGut Microbes and Health Research Programme, Quadram Institute Bioscience, Norwich, United Kingdom.
Udo WegmannSchool of Chemistry, University East Anglia, Norwich, United Kingdom.
Maria GuirroBiochemistry and Biotechnology Department, Nutrigenomics Research Group, Universitat Rovira i Virgili, Tarragona, Spain.
Andrew J GoldsonCore Science Resources Quadram Institute Bioscience, Norwich, United Kingdom.
Arlaine BrionCore Science Resources Quadram Institute Bioscience, Norwich, United Kingdom.
Catherine BoothCore Science Resources Quadram Institute Bioscience, Norwich, United Kingdom.
Padhmanand SudhakarGut Microbes and Health Research Programme, Quadram Institute Bioscience, Norwich, United Kingdom.
Ian R BrownSchool of Biosciences, University of Kent, Canterbury, United Kingdom.
Tamás KorcsmárosGut Microbes and Health Research Programme, Quadram Institute Bioscience, Norwich, United Kingdom.
Simon R CardingGut Microbes and Health Research Programme, Quadram Institute Bioscience, Norwich, United Kingdom.ORCID 0000-0002-2383-9701
Quadram Institute · GBUniversity of East Anglia · GBCentre for Omic Sciences · ESUniversity of Kent · GB

Funding

Biotechnology and Biological Sciences Research Council BB/CSP17270/1Biotechnology and Biological Sciences Research Council BB/J004529/1Biotechnology and Biological Sciences Research Council BB/R012490/1Biotechnology and Biological Sciences Research Council BBS/E/F/000PR10353Biotechnology and Biological Sciences Research Council BBS/E/F/000PR10355Biotechnology and Biological Sciences Research Council BBS/E/F000PR10355Biotechnology and Biological Sciences Research Council BBS/E/F/000PR10356
6 · The paper itself

Abstract

Bacterial extracellular vesicles (BEVs) released from both Gram-negative and Gram-positive bacteria provide an effective means of communication and trafficking of cell signaling molecules. In the gastrointestinal tract (GIT) BEVs produced by members of the intestinal microbiota can impact host health by mediating microbe-host cell interactions. A major unresolved question, however, is what factors influence the composition of BEV proteins and whether the host influences protein packaging into BEVs and secretion into the GIT. To address this, we have analyzed the proteome of BEVs produced by the major human gut symbiont Bacteroides thetaiotaomicron both

Indexed as

Bacteroides thetaiotaomicronExtracellular VesiclesAnimalsAsparaginaseBacteriaDipeptidyl-Peptidases and Tripeptidyl-PeptidasesGastrointestinal MicrobiomeHumansMiceProteomeAsparaginaseDipeptidyl-Peptidases and Tripeptidyl-PeptidasesProteomebacterial extracellular vesiclesBacteroides thetaiotaomicronintestinemicrobiotaproteome

Identifiers

PMID35916501
PMCPMC9397113
OpenAlexW4289521034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.