ArticlemBio2022
Indole Sensing Regulator (IsrR) Promotes Virulence Gene Expression in Enteric Pathogens.
Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 14 citations in OpenAlex.
- Microbiota-derived indole limitsScience advances · 2026Article
- TusDCB-mediated tRNA sulfur modification is required for virulence and intestinal fitness in enterohemorrhagicInfection and immunity · 2026Article
- Indole sensing in host, microbiota, and pathogen interactions.Current opinion in immunology · 2026Review
- Pathogenesis and therapeutic strategies in the interaction between gut microbiota and enterohemorrhagic Escherichia coli infection.FEMS microbiology reviews · 2026Review
- Infection strategies ofGut microbes reports · 2026Review
- Gut microbiome-derived indoles differentially suppress type III secretion system-associated virulence inFrontiers in microbiology · 2026Article
- Indole signaling inGut microbes · 2025Review
- A cell-cell communication signal fromApplied and environmental microbiology · 2025Article
- Enterohemorrhagic E. coli (EHEC) and the microbiome.PLoS pathogens · 2025Article
- Exogenous indole modulates several CpxRA-mediated virulence-related parameters ofMarine life science & technology · 2024Article
- T3SS protein EsrC binds to theApplied and environmental microbiology · 2024Article
- Unraveling the Dynamics of Host-Microbiota Indole Metabolism: An Investigation of Indole, Indolin-2-one, Isatin, and 3-Hydroxyindolin-2-one.Molecules (Basel, Switzerland) · 2024Article
- A response regulator controlsPNAS nexus · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Enteric pathogens such as enterohemorrhagic E. coli (EHEC) and its surrogate murine model Citrobacter rodentium sense indole levels within the gut to navigate its biogeography and modulate virulence gene expression. Indole is a microbiota-derived signal that is more abundant in the intestinal lumen, with its concentration decreasing at the epithelial lining where it is absorbed. E. coli, but not C. rodentium, produces endogenous indole because it harbors the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.