ArticleeLife2022
Disruption in structural-functional network repertoire and time-resolved subcortical fronto-temporoparietal connectivity in disorders of consciousness.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 59 citations in OpenAlex.
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- Dynamic Global and Local Enhancement of Theta-Band Functional Networks as Neural Markers of Spinal Cord Stimulation Efficacy in Disorders of Consciousness.CNS neuroscience & therapeutics · 2026Article
- System-specific reductions of resting-state BOLD signal entropy in disorders of consciousness.Neuroradiology · 2026Article
- Esketamine Preserves Network Connectivity and Promotes Recovery in Consciousness Disorders.CNS neuroscience & therapeutics · 2026Article
- Neuroimaging of Disorder of Consciousness: From Brain Network Mechanisms to Clinical Translation.Journal of clinical neurology (Seoul, Korea) · 2026Review
- Multiscale cardiorespiratory complexity reveals autonomic signatures of Rajyoga meditation.Frontiers in psychology · 2026Article
- Spinal cord stimulation for concurrent improvement of consciousness and spasticity following severe traumatic brain injury: a case study.Frontiers in neuroscience · 2026Article
- Immediate large-scale cortical network changes following acupuncture in patients with disorders of consciousness: a resting-state fNIRS study.Frontiers in neuroscience · 2026Article
- Differential engagement of thalamic nuclei orchestrates consciousness states across anesthesia, sleep, and disorders of consciousness.Communications biology · 2025Article
- Individual trajectories for recovery of neocortical activity in disorders of consciousness.PLoS computational biology · 2025Article
- Disrupted hierarchical organization in disorders of consciousness revealed by fluctuation-dissipation deviations.bioRxiv : the preprint server for biology · 2025Article
- Altered dynamic functional connectivity and reduced higher order information interaction in Parkinson's patients with hyposmia.NPJ systems biology and applications · 2025Article
- EEG microstate analysis in children with prolonged disorders of consciousness.Scientific reports · 2025Article
- Significance of the corpus callosum and inferior fronto-occipital fasciculus in recovery after traumatic brain injury.Neuroradiology · 2025Article
- The Effect of Modular Degeneracy on Neuroimaging Data.Brain connectivity · 2025Article
- Article
- Assess the level of consciousness in patients with disorders of consciousness by combining resting-state and auditory-evoked EEG.Frontiers in neuroscience · 2025Article
- Altered periodic and aperiodic activities in patients with disorders of consciousness.Frontiers in neuroscience · 2025Article
- Prognostic value of quantitative and visual electroencephalography in disorders of consciousness: a retrospective study.Frontiers in neuroscience · 2025Article
- Efficacy of repetitive transcranial magnetic stimulation for consciousness recovery in children with disorders of consciousness following traumatic brain injury.Frontiers in neurology · 2025Article
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Authors and funding
11 authors at 5 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding recovery of consciousness and elucidating its underlying mechanism is believed to be crucial in the field of basic neuroscience and medicine. Ideas such as the global neuronal workspace (GNW) and the mesocircuit theory hypothesize that failure of recovery in conscious states coincide with loss of connectivity between subcortical and frontoparietal areas, a loss of the repertoire of functional networks states and metastable brain activation. We adopted a time-resolved functional connectivity framework to explore these ideas and assessed the repertoire of functional network states as a potential marker of consciousness and its potential ability to tell apart patients in the unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS). In addition, the prediction of these functional network states by underlying hidden spatial patterns in the anatomical network, that is so-called eigenmodes, was supplemented as potential markers. By analysing time-resolved functional connectivity from functional MRI data, we demonstrated a reduction of metastability and functional network repertoire in UWS compared to MCS patients. This was expressed in terms of diminished dwell times and loss of nonstationarity in the default mode network and subcortical fronto-temporoparietal network in UWS compared to MCS patients. We further demonstrated that these findings co-occurred with a loss of dynamic interplay between structural eigenmodes and emerging time-resolved functional connectivity in UWS. These results are, amongst others, in support of the GNW theory and the mesocircuit hypothesis, underpinning the role of time-resolved thalamo-cortical connections and metastability in the recovery of consciousness.
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