Evidence map›Paper›PMID 35916356›Full record

ArticleACS infectious diseases2022

Structure-Activity Relationship of Penem Antibiotic Side Chains Used against Mycobacteria Reveals Highly Active Compounds.

Hunter R Batchelder, Trevor A Zandi, Amit Kaushik, Akul Naik, Elizabeth Story-Roller, Emily C Maggioncalda, Gyanu Lamichhane, Eric L Nuermberger, Craig A Townsend

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hunter R BatchelderDepartment of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Trevor A ZandiT. C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Amit KaushikCenter for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States.
Akul NaikDepartment of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Elizabeth Story-RollerCenter for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States.
Emily C MaggioncaldaCenter for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States.
Gyanu LamichhaneCenter for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States.
Eric L NuermbergerCenter for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States.
Craig A TownsendDepartment of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States.ORCID 0000-0003-2795-7585

Funding

Program of Molecular BiophysicsT32GM135131 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Karen G. Fleming · 2020 to 2026
$5.4M
Development of novel penems for drug-resistant tuberculosisR01AI137329 · NIAID · JOHNS HOPKINS UNIVERSITY · PI NUERMBERGER, ERIC L, TOWNSEND, CRAIG ARTHUR · 2018 to 2022
$3.9M
The Role of Atypical Cell Wall Biology of Mycobacterium abscessus in Pulmonary Infection and TherapyF31HL147392 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MAGGIONCALDA, EMILY · 2019 to 2020
$62k
NHLBI NIH HHS F31 HL147392NIAID NIH HHS R01 AI137329NIGMS NIH HHS T32 GM135131
6 · The paper itself

Abstract

The rise of antibiotic-resistant

Indexed as

Mycobacterium tuberculosisTuberculosis, Multidrug-ResistantAnti-Bacterial AgentsHumansMeropenemStructure-Activity RelationshipAnti-Bacterial AgentsMeropenemantibioticM. abscessusM. tuberculosispenemstructure−activity relationshipβ-lactam

Identifiers

PMID35916356
PMCPMC10029149

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.