Trial reportJournal of the American Heart Association2022
Prediction of Neurological Deterioration After Intracerebral Hemorrhage: The SIGNALS Score.
Trial report in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predictors of early neurological deterioration in patients with intracerebral hemorrhage: a systematic review and meta-analysis.Journal of neurology · 2024Pooled it
- Review
- Surgical Treatment Could Improve Long-Term Functional Outcomes in Intracerebral Hemorrhage Patients With NIHSS ≥ 10.CNS neuroscience & therapeutics · 2025Article
- Clinical, radiological, and radiomics feature-based explainable machine learning models for prediction of neurological deterioration and 90-day outcomes in mild intracerebral hemorrhage.BMC medical imaging · 2025Article
- Short-term mortality prognosis in spontaneous intracranial hemorrhage: A retrospective study at 115 People's Hospital, HCMC, Vietnam.Journal of public health research · 2025Article
- Association between lactate dehydrogenase and 28-day all-cause mortality in patients with non-traumatic intracerebral hemorrhage: A retrospective analysisof the MIMIC-IV database.Biomolecules & biomedicine · 2025Article
- Risk factors and model construction for early neurological deterioration in patients with intracerebral hemorrhage.Frontiers in neurology · 2025Article
- Radiomic Features of Acute Cerebral Hemorrhage on Non-Contrast CT Associated with Patient Survival.Diagnostics (Basel, Switzerland) · 2024Article
- Manifestations and Outcomes of Intracerebral Hemorrhage During the COVID-19 Pandemic in China: Multicenter, Longitudinal Cohort Study.JMIR public health and surveillance · 2023Article
- Ultraearly Intraventricular Hemorrhage Growth Predicts Early Neurologic Deterioration and Poor Functional Outcome After Acute Intracerebral Hemorrhage.Journal of the American Heart Association · 2023Article
- Neurological Deterioration in Intracerebral Hemorrhage: Can We Predict It, and What Would We Do If We Could?Journal of the American Heart Association · 2022Article
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Intracerebral hemorrhage is the most disabling and lethal form of stroke. We aimed to develop a novel clinical score for neurological deterioration during hospitalization after intracerebral hemorrhage. Methods and Results We analyzed data from the CHERRY (Chinese Cerebral Hemorrhage: Mechanism and Intervention) study. Two-thirds of eligible patients were randomly allocated into the training cohort (n=1027) and one-third into the validation cohort (n=515). Multivariable logistic regression was used to identify factors associated with neurological deterioration (an increase in National Institutes of Health Stroke Scale of ≥4 or death) within 15 days after symptom onset. A prediction score was developed based on regression coefficients derived from the logistic model. The site, size, gender, National Institutes of Health Stroke Scale, age, leukocyte, sugar (SIGNALS) score was developed as a sum of individual points (0-8) based on site (1 point for infratentorial location), size (3 points for >20 mL of supratentorial hematoma volume or 2 points for >10 mL of infratentorial hematoma volume), sex (1 point for male sex), National Institutes of Health Stroke Scale score (1 point for >10), age (1 point for ≥70 years), white blood cell (1 point for>9.0×10
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