Evidence map›Paper›PMID 35916034›Full record

ArticleJournal of leukocyte biology2022

Selenoprotein I deficiency in T cells promotes differentiation into tolerant phenotypes while decreasing Th17 pathology.

Chi Ma, FuKun W Hoffmann, Lance G Nunes, Frank Urena, Anastasia Andrukhiv, Mariana Gerschenson, Matthew W Pitts, Peter R Hoffmann

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of leukocyte biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chi MaDepartment of Cell and Molecular Bi ology, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii, Honolulu, USA.
FuKun W HoffmannDepartment of Cell and Molecular Bi ology, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii, Honolulu, USA.
Lance G NunesDepartment of Cell and Molecular Bi ology, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii, Honolulu, USA.
Frank UrenaDepartment of Cell and Molecular Bi ology, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii, Honolulu, USA.
Anastasia AndrukhivDepartment of Cell and Molecular Bi ology, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii, Honolulu, USA.
Mariana GerschensonDepartment of Cell and Molecular Bi ology, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii, Honolulu, USA.
Matthew W PittsDepartment of Cell and Molecular Bi ology, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii, Honolulu, USA.
Peter R HoffmannDepartment of Cell and Molecular Bi ology, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii, Honolulu, USA.
University of Hawaiʻi at Mānoa · USUniversity of Hawaii System · US

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI HELEN C TURNER · 2012 to 2026
$60.3M
TRPA1 Physiology in Diabetes, Metabolic Syndrome, and MetabolismP20GM113134 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Michael A. Ortega · 2017 to 2026
$21.5M
Small Grants ProgramP30GM114737 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI YANAGIHARA, RICHARD · 2015 to 2022
$8.1M
Translational Pilot Project ProgramP30GM131944 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI WARD, WILLIAM S · 2019 to 2023
$5.9M
The Role of Selenoprotein I in Phospholipidethanolamine Dependent Mechanisms that Regulate T Cell ActivationR01AI147496 · NIAID · UNIVERSITY OF HAWAII AT MANOA · PI HOFFMANN, PETER R · 2019 to 2023
$2.1M
NIAID NIH HHS R01 AI147496NIGMS NIH HHS P20 GM103466NIGMS NIH HHS P20 GM113134NIGMS NIH HHS P30 GM114737NIGMS NIH HHS P30 GM131944
6 · The paper itself

Abstract

Selenoprotein I (SELENOI) is an ethanolamine phospholipid transferase contributing to cellular metabolism and the synthesis of glycosylphosphatidylinositol (GPI) anchors. SELENOI knockout (KO) in T cells has been shown to impair metabolic reprogramming during T cell activation and reduce GPI-anchored Thy-1 levels, which are both crucial for Th17 differentiation. This suggests SELENOI may be important for Th17 differentiation, and we found that SELENOI was indeed up-regulated early during the activation of naïve CD4

Indexed as

Nuclear Receptor Subfamily 1, Group F, Member 3Th17 CellsAnimalsCell DifferentiationForkhead Transcription FactorsInterleukin-17MiceMice, Inbred C57BLMice, KnockoutPhenotypeSelenoproteinsForkhead Transcription FactorsInterleukin-17Nuclear Receptor Subfamily 1, Group F, Member 3Selenoproteinsautoimmunityethanolamine phospholipid transferaseinflammationmetabolismphosphatidylethanolamine

Identifiers

PMID35916034
PMCPMC9701159
OpenAlexW4289521648

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.