Evidence map›Paper›PMID 35915966›Full record

ArticleThrombosis and haemostasis2022

Beta-Secretase-1 Antisense RNA Is Associated with Vascular Ageing and Atherosclerotic Cardiovascular Disease.

Dimitrios Bampatsias, Ioannis Mavroeidis, Simon Tual-Chalot, Nikolaos I Vlachogiannis, Francesca Bonini, Marco Sachse, Georgios Mavraganis, Alexia Mareti, Chrysoula Kritsioti, Ageliki Laina and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Thrombosis and haemostasis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. How to measure and model cardiovascular aging.Cardiovascular research · 2025
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  15. Noncoding RNAs as Key Regulators for Cardiac Development and Cardiovascular Diseases.Journal of cardiovascular development and disease · 2023
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 4 countries.

Dimitrios BampatsiasDepartment of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Ioannis MavroeidisDepartment of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Simon Tual-ChalotVascular Biology and Medicine Theme, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Nikolaos I VlachogiannisVascular Biology and Medicine Theme, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Francesca BoniniDepartment of Cardiovascular Research, European Center for Angioscience (ECAS), Heidelberg University, Mannheim, Germany.
Marco SachseDepartment of Cardiovascular Research, European Center for Angioscience (ECAS), Heidelberg University, Mannheim, Germany.
Georgios MavraganisDepartment of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Alexia MaretiDepartment of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Chrysoula KritsiotiDepartment of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Ageliki LainaDepartment of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Dimitrios DelialisDepartment of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Giorgia CilibertiDepartment of Cardiovascular Research, European Center for Angioscience (ECAS), Heidelberg University, Mannheim, Germany.
Kateryna SopovaVascular Biology and Medicine Theme, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Aikaterini GatsiouVascular Biology and Medicine Theme, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Fabio MartelliMolecular Cardiology Laboratory, IRCCS Policlinico San Donato, Milan, Italy.
Georgios GeorgiopoulosDepartment of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Konstantinos StellosVascular Biology and Medicine Theme, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Kimon StamatelopoulosDepartment of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
National and Kapodistrian University of Athens · GRHeidelberg University · DENewcastle University · GBAlexandra Hospital · GRIRCCS Policlinico San Donato · IT

Funding

SFB834 B12, project number 75732319 German Research Foundation DFG
6 · The paper itself

Abstract

backgroundThe noncoding antisense transcript for β-secretase-1 (

methodsExpression of

resultsIn the cross-sectional arm,

conclusion

Indexed as

AgingAtherosclerosisCardiovascular DiseasesRNA, Long NoncodingAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesCarotid Intima-Media ThicknessCross-Sectional StudiesHumansLeukocytes, MononuclearProspective StudiesPulse Wave AnalysisRNA, AntisenseAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesBACE1-AS long non-coding RNA, humanRNA, AntisenseRNA, Long Noncoding

Identifiers

PMID35915966
PMCPMC9626031
OpenAlexW4289528514

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.