ArticleCureus2022
Significance of C-reactive Protein Levels in Categorizing Upper and Lower Urinary Tract Infection in Adult Patients.
Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Retrospective evaluation of C-reactive protein for discriminating between lower urinary tract infections and acute pyelonephritis in dogs.Journal of veterinary internal medicine · 2026Article
- Article
- Clinical Usefulness of Early Evaluation of the Bacteriological Effect of Antibiotics Administered as Empiric Therapy Using the Fully Automated Urine Particle Analyzer UF-5000 in Febrile Urinary Tract Infections.International journal of urology : official journal of the Japanese Urological Association · 2025Article
- Article
- Sustainable nanophytosome-based therapies against multidrug-resistant Escherichia coli in urinary tract infections: an in Vitro and in vivo study.Journal of nanobiotechnology · 2025Article
- Recurrent uncomplicated lower urinary tract infections in women.Current urology · 2025Review
- C-Reactive Protein Monitoring Identifies Urinary Tract Infections in Ambulatory Kidney Transplant Recipients.Canadian journal of kidney health and disease · 2025Article
- Noninvasive, Multimodal Inflammatory Biomarker Discovery for Systemic Inflammation (NOVA Study): Protocol for a Cross-Sectional Study.JMIR research protocols · 2024Article
- Acute phase proteins patterns as biomarkers in bacterial infection: Recent insights.Open veterinary journal · 2024Review
- Innovative Biosensor Technologies in the Diagnosis of Urinary Tract Infections: A Comprehensive Literature Review.Indian journal of microbiology · 2024Review
- Role of estradiol and C-reactive protein levels on genitourinary syndrome in menopausal women.Narra J · 2024Article
- Comprehensive insights into UTIs: from pathophysiology to precision diagnosis and management.Frontiers in cellular and infection microbiology · 2024Review
- Correlation of procalcitonin and c-reactive protein levels with pathogen distribution and infection localization in urinary tract infections.Scientific reports · 2023Article
- Comparison of different ratios of cefoperazone/sulbactam in patients with pyelonephritis.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUrinary tract infections (UTIs) are one of the most commonly encountered infections in outpatients. The distinction between upper UTI and lower UTI is significant as it has therapeutic and prognostic importance. The accurate diagnosis of UTI, especially its anatomical location, is essential for administering anti-microbial therapy successfully. Plasma levels of C-reactive protein (CRP) increase 1,000-fold during bacterial infections. Elevated CRP levels are often seen in acute pyelonephritis and rarely in cystitis. Therefore, this study aimed to evaluate the diagnostic role of serum CRP in upper and lower UTI in adult patients along with correlating its role in UTI patients. MATERIALS AND
methodsThe study included 81 patients who were >18 years old, diagnosed with UTI by microbiological culture and ultrasonography of the pelvis. Demographic data along with findings of the systemic examination, complete blood count, random blood sugar, urine analysis, and CRP levels of all patients were recorded. Data were analyzed using R Studio.3.5.3 software, and a p-value ≤ 0.05 was considered significant.
resultsThe prevalence of UTI was higher among females (60.49%). About 53.09% of patients exhibited upper and 46.91% exhibited lower UTI. The prevalence of
conclusionAbout 53.09% of patients exhibited upper UTI and were diagnosed with acute pyelonephritis. A significant increase in the CRP levels in upper UTI can help determine the anatomical location and can help in targeting effective management of the infection by anti-microbial therapy.
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