Evidence map›Paper›PMID 35915604›Full record

ArticleInternational journal of pediatrics2022

Alteration of Plasma Amino Acid Concentrations in Iranian Children with COVID-19.

Sedigheh Shams, Aileen Azari-Yam, Moeinadin Safavi, Zahra Zamani, Maryam Sotoudeh-Anvari, Meisam Sharifzadeh Ekbatani, Mohammad-Taghi Haghi-Ashtiani, Fatemeh Mozafari, Bahareh Yaghmaie, Leila Shafeghat

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Sedigheh ShamsPathology Department, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-4628-9925
Aileen Azari-YamMolecular Pathology and Cytogenetic Division, Pathology Department, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-9061-7279
Moeinadin SafaviMolecular Pathology and Cytogenetic Division, Pathology Department, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-4042-7506
Zahra ZamaniPediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0001-7826-440X
Maryam Sotoudeh-AnvariMolecular Pathology and Cytogenetic Division, Pathology Department, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0003-2318-8571
Meisam Sharifzadeh EkbataniDivision of Pediatric Intensive Care Unit, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-0936-5941
Mohammad-Taghi Haghi-AshtianiPathology Department, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Fatemeh MozafariPediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Bahareh YaghmaieDivision of Pediatric Intensive Care Unit, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0003-2850-8888
Leila ShafeghatPediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Children's Medical Center · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 is an acute viral disease that has so far infected more than 200 million and killed more than four million worldwide. It affects the immune system and other organs. Here, we investigated the level of free plasma amino acids in COVID-19 patients and compared them with non-COVID-19 subjects. We also compared amino acids levels in critically ill patients admitted to the intensive care unit (ICU) with non-ICU patients and expired and recovered patients. Twenty-six COVID-19 patients and 32 non-COVID-19 subjects were included in the study. The mean of glutamic acid, serine, glycine, threonine, phenylalanine, leucine, lysine, alanine, arginine, aspartic acid, and ornithine was significantly higher in cases than controls. In addition, the mean of glutamine was significantly lower in patients than controls (443.89 ± 254.31 vs. 651.73 ± 107.38, PV < 0.001). Low level of glutamine and isoleucine was seen in the majority of ICU and expired patients, respectively. Logistic regression analysis showed low level of isoleucine as a predictor variable in mortality (

Identifiers

PMID35915604
PMCPMC9338730
OpenAlexW4288715350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.