ArticleThe journal of physiological sciences : JPS2022
Hypergravity load-induced hyperglycemia occurs due to hypothermia and increased plasma corticosterone level in mice.
Article in The journal of physiological sciences : JPS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 3 citations in OpenAlex.
- Limb restraint induces a rapid and profound decrease in core body temperature associated with the stress response in mice.PNAS nexus · 2026Article
- Hypergravity exposure leads to persistent effects on geotaxis and activity in Drosophila melanogaster.The Journal of experimental biology · 2026Article
- Gravitational change-induced alteration of the vestibular function and gene expression in the vestibular ganglion of mice.The journal of physiological sciences : JPS · 2024Article
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8 authors at 2 institutions in 1 country.
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Abstract
Hypothermia has been observed during hypergravity load in mice and rats. This response is beneficial for maintaining blood glucose level, although food intake decreases. However, saving glucose is not enough to maintain blood glucose level during hypergravity load. In this study, we examined the contribution of humoral factors related to glycolysis in maintaining blood glucose level in a 2 G environment. Increased plasma corticosterone levels were observed in mice with intact peripheral vestibular organs, but not in mice with vestibular lesions. Plasma glucagon levels did not change, and decrease in plasma adrenaline levels was observed in mice with intact peripheral vestibular organs. Accordingly, it is possible that increase in plasma corticosterone level and hypothermia contribute to prevent hypoglycemia in a 2 G environment.
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