Evidence map›Paper›PMID 35915405›Full record

ArticleBMC cardiovascular disorders2022

Long-term outcome of a pragmatic trial of multifaceted intervention (STROKE-CARD care) to reduce cardiovascular risk and improve quality-of-life after ischaemic stroke and transient ischaemic attack: study protocol.

Christian Boehme, Lena Domig, Silvia Komarek, Thomas Toell, Lukas Mayer, Benjamin Dejakum, Stefan Krebs, Raimund Pechlaner, Alexandra Bernegger, Christoph Mueller and 9 more

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02156778 nacompletednot on this map

Multifaceted Intervention to Reduce Recurrent Cardiovascular Events and Improve Quality-of-Life After Ischemic Stroke and High-Risk Transient Ischemic Attack (TIA)

TypeinterventionalSponsorMedical University InnsbruckRan2014 to 2019Enrolled2,149ConditionsStroke, Ischemic Attack, Transient, Secondary Prevention, Disease ManagementArmsActive Comparator: Extended Standard Care (Stroke Card), Active Comparator: Standard Care
NCT04205006 unknown statusnot on this map

Long-term Outcome of a Pragmatic Trial of Multifaceted Intervention (STROKE-CARD Care) to Reduce Cardiovascular Risk and Improve Quality-of-life After Ischemic Stroke and Transient Ischemic Attack

TypeobservationalSponsorMedical University InnsbruckRan2019 to 2022Enrolled1,000ConditionsIschemic Stroke, TIA
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Christian Boehme *Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Lena Domig *Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Silvia KomarekDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Thomas ToellDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Lukas MayerDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Benjamin DejakumDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Stefan KrebsDepartment of Neurology, Hospital St. John's of God, Vienna, Austria.
Raimund PechlanerDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Alexandra BerneggerDepartment of Neurology, Hospital St. John's of God, Vienna, Austria.
Christoph MuellerDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Gerhard RumpoldDepartment of Medical Psychology, Medical University of Innsbruck, Innsbruck, Austria.
Andrea GriesmacherCentral Institute of Medical and Chemical Laboratory Diagnostics, University Hospital of Innsbruck, Innsbruck, Austria.
Marion ViglDepartment of Neurology, Hospital St. John's of God, Vienna, Austria.
Gudrun SchoenherrDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Christoph SchmidauerDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Julia FerrariDepartment of Neurology, Hospital St. John's of God, Vienna, Austria.
Wilfried LangDepartment of Neurology, Hospital St. John's of God, Vienna, Austria.
Michael KnoflachDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Stefan KiechlDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria. stefan.kiechl@i-med.ac.at.ORCID 0000-0002-9836-2514
Innsbruck Medical University · ATHospital of the Brothers of St. John of God · ATSigmund Freud Privatuniversität Wien · ATUniversity Hospital Innsbruck · AT

Funding

VASCage-C FSG 868624
6 · The paper itself

Abstract

backgroundPatients with ischaemic stroke or transient ischaemic attack (TIA) are at high risk of incident cardiovascular events and recurrent stroke. Despite compelling evidence about the efficacy of secondary prevention, a substantial gap exists between risk factor management in real life and that recommended by international guidelines. We conducted the STROKE-CARD trial (NCT02156778), a multifaceted pragmatic disease management program between 2014 and 2018 with follow-up until 2019. This program successfully reduced cardiovascular risk and improved health-related quality of life and functional outcome in patients with acute ischaemic stroke or TIA within 12 months after the index event. To investigate potential long-term effects of STROKE-CARD care compared to standard care, an extension of follow-up is warranted.

methodsWe aim to include all patients from the STROKE-CARD trial (n = 2149) for long-term follow-up between 2019 and 2021 with the study visit scheduled 3-6 years after the stroke/TIA event. The co-primary endpoint is the composite of major recurrent cardiovascular events (nonfatal stroke, nonfatal myocardial infarction, and vascular death) from hospital discharge until the long-term follow-up visit and health-related quality of life measured with the European Quality of Life-5 Dimensions (EQ-5D-3L) at the final visit. Secondary endpoints include overall mortality, long-term functional outcome, and target-level achievement in risk factor management. DISCUSSION: This long-term follow-up will provide evidence on whether the pragmatic post-stroke/TIA intervention program STROKE-CARD is capable of preventing recurrent cardiovascular events and improving quality-of-life in the long run. Trial registration clinicaltrials.gov: NCT04205006 on 19 December 2019.

Indexed as

Brain IschemiaCardiovascular DiseasesIschemic Attack, TransientIschemic StrokeStrokeHeart Disease Risk FactorsHumansQuality of LifeRisk FactorsSecondary PreventionDisease management programIschaemic strokeStroke long-term follow-upStroke secondary preventionTransient ischaemic attack

Identifiers

PMID35915405
PMCPMC9344624
OpenAlexW4289262038

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.