SynthesisQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2023
Measurement properties of the EQ-5D in populations with a mean age of ≥ 75 years: a systematic review.
Synthesis in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Preference-based measures in people with dementia: a systematic review of psychometric properties.Health and quality of life outcomes · 2026Pooled it
- Economic evidence related to the use of community assets in the management of frailty: a systematic review.Frontiers in public health · 2026Pooled it
- Trial
- Path model explaining the association between fear of falling and health-related quality of life in (pre-)frail older adults.BMC geriatrics · 2025Trial
- A Review of the Application of Generic Preference-Based Instruments with Older People Across Care Settings.Applied health economics and health policy · 2026Review
- Article
- Higher cost, comparable outcomes: A health economic evaluation of patient-specific instrumentation vs. conventional instrumentation for total knee arthroplasty in a Dutch aging population.Journal of experimental orthopaedics · 2025Article
- Lateral unicompartmental knee arthroplasty is an effective procedure for lateral post-meniscectomy knee osteoarthritis: a case-control study at a mean 7-year follow-up.Journal of orthopaedic surgery and research · 2025Article
- What patient-reported outcome measures may be suitable for research involving older adults with frailty? A scoping review.European geriatric medicine · 2024Article
- Measuring Quality of Life in Deprescribing Trials: A Scoping Review.Drugs & aging · 2024Article
- Newly developed care food enhances grip strength in older adults with dysphagia: a preliminary study.Nutrition research and practice · 2023Article
- Exploring differences and similarities of EQ-5D-3L, EQ-5D-5L and WHOQOL-OLD in recipients of aged care services in Germany.PloS one · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHealthcare interventions for middle-old and oldest-old individuals are often (economically) evaluated using the EQ-5D to measure health-related quality of life (HrQoL). This requires sufficient measurement properties of the EQ-5D. Therefore, the current study aimed to systematically review studies assessing the measurement properties of the EQ-5D in this population.
methodsThe databases PubMed, Cochrane library, Web of Science, Embase, and EconLit were searched for studies providing empirical evidence of reliability, validity, and/or responsiveness of the EQ-5D-3L and EQ-5D-5L in samples with a mean age ≥ 75 years. Studies were selected by two independent reviewers, and the methodological quality was assessed using the COSMIN Risk of Bias checklist. Results were rated against updated criteria for good measurement properties (sufficient, insufficient, inconsistent, indeterminate). The evidence was summarized, and the quality of evidence was graded using a modified GRADE approach.
resultsFor both EQ-5D versions, high-quality evidence for sufficient convergent validity was found. Known-groups validity was sufficient for the EQ-5D-5L (high-quality evidence), whereas the results were inconsistent for the EQ-5D-3L. Results regarding the reliability were inconsistent (EQ-5D-3L) or entirely lacking (EQ-5D-5L). Responsiveness based on correlations of change scores with instruments measuring related/similar constructs was insufficient for the EQ-5D-3L (high-quality evidence). For the EQ-5D-5L, the available evidence on responsiveness to change in (Hr)QoL instruments was limited.
conclusionSince the responsiveness of the EQ-5D in a population of middle-old and oldest-old individuals was questionable, either using additional instruments or considering the use of an alternative, more comprehensive instrument of (Hr)QoL might be advisable, especially for economic evaluations.
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