ArticleNature chemistry2022
Photochemical single-step synthesis of β-amino acid derivatives from alkenes and (hetero)arenes.
Article in Nature chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Conversion of Alkenes Into Simple or Functionalized Aldehydes by Reaction With an Ambiphilic Masked Formyl Radical.Angewandte Chemie (International ed. in English) · 2026Article
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- Recent advances in polymeric chemically amplified positive resists: Materials and design strategies.Smart molecules : open access · 2026Review
- N-O Dual Functional Group Transposition via Energy Transfer Photocatalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Aziridination of a Single Carbon Atom in Alkenes via Energy Transfer Catalysis.Angewandte Chemie (International ed. in English) · 2026Article
- Photochemical, electrochemical and electrophotochemical C-N bond-forming cross-coupling reactions.Nature reviews. Chemistry · 2026Review
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- Bench-stable reagents for modular access to persulfuranyl scaffolds.Nature communications · 2025Article
- Enantioselective Alkoxycarbonyl-Lactonization of Alkenes via the Merger of Photoredox and Copper Catalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Asymmetric synthesis of β-amino acid derivatives by stereocontrolled C(spNature communications · 2025Article
- Harnessing Bifunctional N-Benzoyloxyamides for Photoredox Amidative Dual Functionalizations of Alkenes.Angewandte Chemie (International ed. in English) · 2025Article
- Efficient and selective energy transfer photoenzymes powered by visible light.Nature chemistry · 2025Article
- closo-Carboranyl Analogs of β-Arylethylamines: Direct Synthesis from Alkenes via EnT-Catalysis.Angewandte Chemie (International ed. in English) · 2025Article
- Biomimetic 1,2-amino migration via photoredox catalysis.Nature chemistry · 2025Article
- Selective Synthesis of Tetrahydroisoquinoline and Piperidine Scaffolds by Oxidative Ring Opening/Ring Closing Protocols of Substituted Indenes and Cyclopentenes.ChemistryOpen · 2025Article
- Cyclic Bifunctional Reagents Enabling a Strain-Release-Driven Formal [3 + 2] Cycloaddition of 2Journal of the American Chemical Society · 2025Article
- Visible light-mediated dearomative spirocyclization/imination of nonactivated arenes through energy transfer catalysis.Nature communications · 2025Article
- Development of N-centered radical scavengers that enables photoredox-catalyzed transition-metal-free radical amination of alkyl pinacol boronates.Nature communications · 2025Article
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6 authors.
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Abstract
β-Amino acids are frequently found as important components in numerous biologically active molecules, drugs and natural products. In particular, they are broadly utilized in the construction of bioactive peptides and peptidomimetics, thanks to their increased metabolic stability. Despite the number of methodologies established for the preparation of β-amino acid derivatives, the majority of these methods require metal-mediated multistep manipulations of prefunctionalized substrates. Here we disclose a metal-free, energy-transfer enabled highly regioselective intermolecular aminocarboxylation reaction for the single-step installation of both amine and ester functionalities into alkenes or (hetero)arenes. A bifunctional oxime oxalate ester was developed to simultaneously generate C-centred ester and N-centred iminyl radicals. This mild method features a remarkably broad substrate scope (up to 140 examples) and excellent tolerance of sensitive functional groups, and substrates that range from the simplest ethylene to complex (hetero)arenes can participate in the reaction, thus offering a general and practical access to β-amino acid derivatives.
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