ArticleEye (London, England)2023
Systemic disease associations with angioid streaks in a large healthcare claims database.
Article in Eye (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 10 citations in OpenAlex.
- Clinical characteristics of angioid streaks in Japanese patients.Japanese journal of ophthalmology · 2026Observational
- Paget's disease of bone: pathogenesis, ocular manifestations, and therapeutic strategies.Orphanet journal of rare diseases · 2026Review
- [Angioid streaks as a possible sign of an underlying systemic disease].Die Ophthalmologie · 2026Article
- Angioid streaks in hereditary spherocytosis associated with an SPTB gene variant.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- [Bilateral choroidal neovascularization of rare origin : Secondary choroidal neovascularization in angioid streaks].Die Ophthalmologie · 2025Article
- Abetalipoproteinemia with angioid streaks, choroidal neovascularization, atrophy, and extracellular deposits revealed by multimodal retinal imaging.Ophthalmic genetics · 2024Article
- Long-term functional, anatomical outcome, and qualitative analysis by OCTA, as a predictor of disease recurrences in patients with choroidal neovascularization secondary to angioid streaks.International journal of retina and vitreous · 2024Article
- Improving clinical management of macular neovascularisation secondary to angioid streaks.Eye (London, England) · 2024Article
- Angioid Streaks Remain a Challenge in Diagnosis, Management, and Treatment.Vision (Basel, Switzerland) · 2024Review
- Optic disc drusen: Recent developments on a slow-moving condition.Taiwan journal of ophthalmologyReview
- Choroidal neovascularization secondary to angioid streaks in a patient with pseudoxanthoma elasticum: case report.Romanian journal of ophthalmologyArticle
- Bilateral angioid streaks in a young patient with pseudoxanthoma elasticum.Oman journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND/
objectivesTo assess systemic associations of angioid streaks (AS) using a large US healthcare database. SUBJECTS/
methodsA retrospective cross-sectional study was conducted of patients diagnosed with AS in a large, national US insurer from 2000-2019. Cases were matched 1:5 to controls. The prevalence rates of established associated disease states and other systemic diseases were calculated and compared using logistic regression. Additionally, the rate of anti-VEGF treatment was assessed as a proxy for the incidence of choroidal neovascularization (CNV).
resultsOne thousand eight hundred fifty-two cases of AS and 9028 matched controls were included. The rates of association between AS and the well-characterized conditions included: Pseudoxanthoma elasticum (PXE)-228 patients (12.3%), Ehlers-Danlos syndrome-18 patients (1.0%), Paget's disease-6 patients (0.3%), hemoglobinopathies-30 patients (1.6%), and idiopathic-1573 patients (84.9%). There was a statistically higher prevalence of the following less classically associated diseases among patients with AS compared to controls: hereditary spherocytosis (1.7% vs. 0.6%, p < 0.001), connective tissue disease (1.0% vs 0.3%, p < 0.001) and non-exudative age-related macular degeneration (33.9% vs 10.6%, p < 0.001). Among 1442 eligible cases analyzed, 427 (29.6%) received at least 1 anti-VEGF injection with 338 (23.4%) patients having the injection after their AS diagnosis.
conclusionsIn the largest collection of AS patients to date, the classical teaching of systemic disease associations occur at rates far, far lower than previously reported. The association of AS with other less reported diseases highlights new potential associations and may contribute to the understanding of AS formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.