ArticleNature neuroscience2022
Temporally divergent regulatory mechanisms govern neuronal diversification and maturation in the mouse and marmoset neocortex.
Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- The Role of Astrocyte-Neuron Interactions in Shaping Neuronal Maturation during Human Brain Development.Computational and structural biotechnology journal · 2026Article
- A single-cell spatiotemporal transcriptomic atlas of mouse prefrontal cortex maps dynamics of intratelencephalic neurons during postnatal development.PLoS biology · 2026Article
- Sox11 overexpression restores embryonic pro-growth transcription in mature corticospinal tract neurons.Scientific reports · 2025Article
- The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube.Developmental cell · 2025Article
- Sox11 overexpression restores embryonic pro-growth transcription in mature corticospinal tract neurons.bioRxiv : the preprint server for biology · 2025Article
- Elevated EGR1 binding at enhancers in excitatory neurons correlates with neuronal subtype-specific epigenetic regulation.BMC biology · 2025Article
- scMultiNODE: Integrative and Scalable Framework for Multi-Modal Temporal Single-Cell Data.bioRxiv : the preprint server for biology · 2025Article
- Progranulin deficiency in the brain: the interplay between neuronal and non-neuronal cells.Translational neurodegeneration · 2025Review
- Dual role of FOXG1 in regulating gliogenesis in the developing neocortex via the FGF signalling pathway.eLife · 2025Article
- Multiplexed CRISPRi Reveals a Transcriptional Switch Between KLF Activators and Repressors in the Maturing Neocortex.bioRxiv : the preprint server for biology · 2025Article
- Bridging animal models and humans: neuroimaging as intermediate phenotypes linking genetic or stress factors to anhedonia.BMC medicine · 2025Article
- Cortical arealization of interneurons defines shared and distinct molecular programs in developing human and macaque brains.Nature communications · 2025Article
- Article
- Cell Type-Specific Profiles and Developmental Trajectories of Transcriptomes in Primate Prefrontal Layer 3 Pyramidal Neurons: Implications for Schizophrenia.The American journal of psychiatry · 2024Article
- Making Ramón y Cajal proud: Development of cell identity and diversity in the cerebral cortex.Neuron · 2024Review
- Gene-environmental regulation of the postnatal post-mitotic neuronal maturation.Trends in genetics : TIG · 2024Review
- Epigenetic control and manipulation of neuronal maturation timing.Current opinion in genetics & development · 2024Review
- Review
- Polygenic risk for schizophrenia converges on alternative polyadenylation as molecular mechanism underlying synaptic impairment.bioRxiv : the preprint server for biology · 2024Article
- CellGO: a novel deep learning-based framework and webserver for cell-type-specific gene function interpretation.Briefings in bioinformatics · 2023Article
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
Mammalian neocortical neurons span one of the most diverse cell type spectra of any tissue. Cortical neurons are born during embryonic development, and their maturation extends into postnatal life. The regulatory strategies underlying progressive neuronal development and maturation remain unclear. Here we present an integrated single-cell epigenomic and transcriptional analysis of individual mouse and marmoset cortical neuron classes, spanning both early postmitotic stages of identity acquisition and later stages of neuronal plasticity and circuit integration. We found that, in both species, the regulatory strategies controlling early and late stages of pan-neuronal development diverge. Early postmitotic neurons use more widely shared and evolutionarily conserved molecular regulatory programs. In contrast, programs active during later neuronal maturation are more brain- and neuron-specific and more evolutionarily divergent. Our work uncovers a temporal shift in regulatory choices during neuronal diversification and maturation in both mice and marmosets, which likely reflects unique evolutionary constraints on distinct events of neuronal development in the neocortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.