ReviewNature neuroscience2022
The central nucleus of the amygdala and the construction of defensive modes across the threat-imminence continuum.
Review in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
76 citing papers in PubMed, 105 citations in OpenAlex.
- Nocturnal Risk Assessment and Its Association With Anxiety Symptoms.Psychophysiology · 2026Trial
- PAG-dependent defensive strategy selection: From stress-induced rigidity to adaptive flexibility.iScience · 2026Article
- Neuro-immune interactions in tumors, immune-related disorders, and infections.Signal transduction and targeted therapy · 2026Review
- Cannabinoid modulation of central amygdala population dynamics during threat investigation.Nature communications · 2026Article
- Amygdalostriatal transition zone neurons encode sustained cue responses to guide defensive behaviors.Neuron · 2026Article
- High-fat diet exposure, internal state, and reward value influence decision making during motivational conflict.Neurobiology of stress · 2026Article
- Cardiac vagal activity during in-vivo threat exposure is associated with within-session inhibition of fear and avoidance.Translational psychiatry · 2026Article
- Serotonergic Modulation of Social Dominance via the Dorsal Raphe-Central Amygdala Circuit in Male Mice.Integrative zoology · 2026Article
- Grooming as a window into the post-stress recuperative process.bioRxiv : the preprint server for biology · 2026Article
- GABAergic Inhibition from the Nucleus Tractus Solitarius to Ventrolateral Medulla Phox2b Neurons Modulates Central Respiratory Chemoreflex and Ventilatory Homeostasis.Neuroscience bulletin · 2026Article
- CGRP receptor-expressing neurons in the central amygdala contributes to injury-induced pain hypersensitivity.bioRxiv : the preprint server for biology · 2026Article
- Nps-Expressing Neurons Receive Extensive Input From Auditory Brainstem Nuclei.The Journal of comparative neurology · 2026Article
- Dorsal Raphe VIP Neurons Are Critical for Survival-Oriented Vigilance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Devaluation of response-produced safety signals reveals circuits for goal-directed versus habitual avoidance in dorsal striatum.Nature communications · 2026Article
- Fear, anxiety, and the extended amygdala-absence of evidence for strict functional segregation.Social cognitive and affective neuroscience · 2026Article
- Stress induces oxytocin-Gαi-dependent remodeling of astrocytes to shape neuronal response in the amygdala.Nature communications · 2025Article
- Ferrimagnetic Vortex Nanorings Facilitate Efficient and Safe Deep-Brain Magnetothermal Stimulation in Freely Moving Mice.Exploration (Beijing, China) · 2025Article
- Igfbp2 Downregulation in PVT-CeA Glutamatergic Circuits Drives Neonatal Anesthesia-Induced Fear Memory Deficits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Parvalbumin interneurons gate amygdala excitability and response to chronic stress via kainate receptor-driven tonic GABAMolecular psychiatry · 2025Article
- Fear, anxiety, and the extended amygdala-bioRxiv : the preprint server for biology · 2025Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
In nature, animals display defensive behaviors that reflect the spatiotemporal distance of threats. Laboratory-based paradigms that elicit specific defensive responses in rodents have provided valuable insight into the brain mechanisms that mediate the construction of defensive modes with varying degrees of threat imminence. In this Review, we discuss accumulating evidence that the central nucleus of the amygdala (CeA) plays a key role in this process. Specifically, we propose that the mutually inhibitory circuits of the CeA use a winner-takes-all strategy that supports transitioning across defensive modes and the execution of specific defensive behaviors to previously formed threat associations. Our proposal provides a conceptual framework in which seemingly divergent observations regarding CeA function can be interpreted and identifies various areas of priority for future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.