SynthesisNature genetics2022
Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 9 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 9 pooled it
21.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 9 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Development and validation of a multiancestry and multitrait polygenic risk score for lung cancer.Nature communications · 2026Pooled it
- Genome-wide meta-analysis across East Asian and European populations provides insights into the molecular basis of lung cancer.Genome medicine · 2026Pooled it
- Cross-ancestry meta-analysis identifies a GSTP1 variant in the polycyclic aromatic hydrocarbons metabolism-related pathway contributing to colorectal cancer susceptibility.Archives of toxicology · 2026Pooled it
- Differences in the risk association of TERT rs2736098 (C > T) with lung cancer between Caucasian and Asian populations: A meta-analysis.Scientific reports · 2025Pooled it
- Trans-ethnic GWAS meta-analysis of idiopathic spermatogenic failure highlights the immune-mediated nature of Sertoli cell-only syndrome.Communications biology · 2025Pooled it
- Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk.Nature communications · 2024Pooled it
- Association of rs401681 (C > T) and rs402710 (C > T) polymorphisms in the CLPTM1L region with risk of lung cancer: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Pooled it
- Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.Nature communications · 2023Pooled it
- SPLENDID incorporates continuous genetic ancestry in biobank-scale data to improve polygenic risk prediction across diverse populations.Nature methods · 2026Article
- Thirty-year changes and future tendencies in Asian burden of tracheal, bronchus, and lung cancer: insights from the Global Burden of Disease Study.Journal of thoracic disease · 2026Article
- Germline determinants of risk and molecular subtype in young-onset lung cancer.medRxiv : the preprint server for health sciences · 2026Article
- Dual E-Cigarette Users Show Nicotine Addiction Risk Alleles and Nuclear Abnormalities in Oral Epithelial Cells.Advances in respiratory medicine · 2026Article
- Faster CYP2A6 increases COPD and lung cancer risk by increasing smoking quantity: a mediated mendelian randomization and observational mediation study.Respiratory research · 2026Observational
- Causal and shared genetic insights into severe COVID-19 and idiopathic pulmonary fibrosis.iScience · 2026Article
- Low genetic risk for coronary artery disease underlies multigenerational longevity and healthy aging.GeroScience · 2026Article
- Accelerating discovery of cancer causes for prevention in the era of rising early-onset cancers.Cell · 2026Review
- Inherited genetic risk factors in young-onset lung cancer.medRxiv : the preprint server for health sciences · 2026Article
- Single-cell full-length transcriptome of human lung reveals genetic effects on isoform regulation beyond gene-level expression.bioRxiv : the preprint server for biology · 2026Article
- Single-cell lung eQTL dataset of Asian never-smokers highlights the roles of alveolar cells in lung cancer etiology.bioRxiv : the preprint server for biology · 2026Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
85 authors at 20 institutions in 15 countries.
Jinyoung Byun *Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0001-8579-1435
Younghun Han *Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0001-5048-8479
Yafang Li *Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.
Jun Xia *Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0001-7331-0673
Erping Long *Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Jiyeon ChoiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-0955-2384
Xiangjun XiaoInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.
Meng ZhuDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, P. R. China.
Wen ZhouInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0001-6872-2761
Ryan SunDepartment of Biostatistics, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA.
Yohan BosséInstitut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Department of Molecular Medicine, Laval University, Quebec City, Quebec, Canada.
Zhuoyi SongInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.
Ann SchwartzDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
Christine LuskDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
Thorunn RafnardeCODE genetics/Amgen Sturlugata 8, Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-0491-7046
Kari StefanssondeCODE genetics/Amgen Sturlugata 8, Reykjavik, Iceland.
Tongwu ZhangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-2124-2706
Wei ZhaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-5103-3871
Rowland W PettitInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.
Yanhong LiuSection of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Xihao LiDepartment of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8151-0106
Hufeng ZhouDepartment of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA, USA.
Kyle M WalshDuke Cancer Institute, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0002-5879-9981
Ivan GorlovInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.
Olga GorlovaInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.
Dakai ZhuInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.
Susan M RosenbergDan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0003-1444-473X
Susan PinneyUniversity of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0003-3491-1980
Joan E Bailey-WilsonNational Human Genome Research Institute, NIH, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-9153-2920
Diptasri MandalLouisiana State University Health Sciences Center, New Orleans, LA, USA.
Mariza de AndradeMayo Clinic, College of Medicine, Rochester, MN, USA.
Colette GabaThe University of Toledo College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
James C WilleyThe University of Toledo College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
Ming YouCenter for Cancer Prevention, Houston Methodist Research Institute, Houston, TX, USA.
Marshall AndersonUniversity of Cincinnati College of Medicine, Cincinnati, OH, USA.
John K WienckeDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Stephan LamDepartment of Integrative Oncology, BC Cancer, Vancouver, British Columbia, Canada.
Adonina TardonPublic Health Department, University of Oviedo, ISPA and CIBERESP, Asturias, Spain.ORCID http://orcid.org/0000-0001-5150-1209
Chu ChenProgram in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Gary GoodmanSwedish Cancer Institute, Seattle, WA, USA.
Stig BojesonDepartment of Clinical Biochemistry, Herlev Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-4061-4133
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-6129-1572
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-4507-329X
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-2324-3393
Mattias JohanssonSection of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France.ORCID http://orcid.org/0000-0002-3116-5081
Thomas MuleyDivision of Cancer Epigenomics, DKFZ - German Cancer Research Center, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-8141-0604
Angela RischDivision of Cancer Epigenomics, DKFZ - German Cancer Research Center, Heidelberg, Germany.
H-Erich WichmannInstitute of Epidemiology, Helmholtz Center, Munich, Germany.
Heike BickeböllerDepartment of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0002-3361-5488
David C ChristianiDepartment of Epidemiology, Harvard T.H.Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0301-0242
Gad RennertClalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.ORCID http://orcid.org/0000-0002-8512-068X
Susanne ArnoldUniversity of Kentucky, Markey Cancer Center, Lexington, KY, USA.ORCID http://orcid.org/0000-0001-6542-9551
John K FieldRoy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.
Sanjay SheteDepartment of Biostatistics, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0001-7622-376X
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Olle MelanderFaculty of Medicine, Lund University, Lund, Sweden.
Hans BrunnstromFaculty of Medicine, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0001-7402-138X
Geoffrey LiuUniversity Health Network- The Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Angeline S AndrewDepartments of Epidemiology and Community and Family Medicine, Dartmouth College, Hanover, NH, USA.
Lambertus A KiemeneyRadboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-2368-1326
Hongbing ShenDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, P. R. China.ORCID http://orcid.org/0000-0002-2581-5906
Shanbeh ZienolddinyNational Institute of Occupational Health, Oslo, Norway.
Kjell GrankvistDepartment of Medical Biosciences, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0003-4289-2097
Mikael JohanssonDepartment of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0003-4182-8923
Neil CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Angela CoxDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, UK.ORCID http://orcid.org/0000-0002-5138-1099
Yun-Chul HongDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jian-Min YuanUPMC Hillman Cancer Center and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-4620-3108
Philip LazarusDepartment of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, WA, USA.
Matthew B SchabathDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.ORCID http://orcid.org/0000-0003-3241-3216
Melinda C AldrichDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-3833-8448
Alpa PatelAmerican Cancer Society, Atlanta, GA, USA.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Fiona TaylorDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
Linda KachuriDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
John S WitteDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.
Lori C SakodaDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.ORCID http://orcid.org/0000-0002-0900-5735
Margaret SpitzSection of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Paul BrennanSection of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France.ORCID http://orcid.org/0000-0002-0518-8714
Xihong LinDepartment of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7067-7752
James McKaySection of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France.ORCID http://orcid.org/0000-0002-1787-3874
Rayjean J HungLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Christopher I AmosInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA. Chris.Amos@bcm.edu.ORCID http://orcid.org/0000-0002-8540-7023
Baylor College of Medicine · USNational Institutes of Health · USCentre international de recherche sur le cancer · FRHarvard University · USGerman Cancer Research Center · DEdeCODE Genetics (Iceland) · ISLund University · SENanjing Medical University · CNThe University of Texas MD Anderson Cancer Center · USUniversity of California, San Francisco · USUniversity of Cincinnati Medical Center · USUniversity of Sheffield · GBUniversity of Toledo · USWayne State University · USAmerican Cancer Society · USCarmel Medical Center · ILDartmouth College · USDuke Medical Center · USFred Hutch Cancer Center · USHelmholtz Zentrum München · DE
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8MWomen's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI Laura Fish · 1985 to 2026
$174.8MTRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5MLaboratory of Translational GenomicsZIACP010201 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI PROKUNINA-OLSSON, LIUDMILA · 2010 to 2025
$91.2MTumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9MREPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4MTranslating Molecular and Clinical Data to Population Lung Cancer Risk AssessmentU19CA203654 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Christopher I. Amos, Rayjean J. Hung · 2017 to 2026
$23.7MGenetic Epidemiology of CancerZIAHG200331 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BAILEY-WILSON, JOAN ELLEN · 2009 to 2022
$11.7MStatistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9MHarnessing Proteins as Drugs: the Protectome of Cancer- and Aging-Prevention ProteinsDP1AG072751 · NIA · BAYLOR COLLEGE OF MEDICINE · PI ROSENBERG, SUSAN M · 2020 to 2024
$5.6MSequencing Familial Lung CancerR01CA243483 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Christopher I. Amos, DIPTASRI M MANDAL · 2023 to 2026
$4.2MMechanisms of Endogenous DNA Damage PromotionR01CA250905 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MILLER, KYLE M, ROSENBERG, SUSAN M · 2020 to 2024
$3.3MNCI NIH HHS P30 CA014236NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA076292NCI NIH HHS P30 CA125123NCI NIH HHS R01 CA243483NCI NIH HHS R01 CA250905NCI NIH HHS R03 CA256222NCI NIH HHS R35 CA197449NCI NIH HHS U01 CA167462NCI NIH HHS U01 CA243483NCI NIH HHS U19 CA203654NCRR NIH HHS S10 RR024574NHLBI NIH HHS 75N92020C00001NHLBI NIH HHS HHSN268201700012CNIA NIH HHS DP1 AG072751NIEHS NIH HHS K99 ES033259NIEHS NIH HHS P30 ES006096NIEHS NIH HHS R00 ES033259NIEHS NIH HHS T32 ES027801World Health Organization 001
Abstract
To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association studies in European, East Asian and African populations and discovered five loci that have not been previously reported. We replicated 26 signals and identified 10 new lead associations from previously reported loci. Rare-variant associations tended to be specific to populations, but even common-variant associations influencing smoking behavior, such as those with CHRNA5 and CYP2A6, showed population specificity. Fine-mapping and expression quantitative trait locus colocalization nominated several candidate variants and susceptibility genes such as IRF4 and FUBP1. DNA damage assays of prioritized genes in lung fibroblasts indicated that a subset of these genes, including the pleiotropic gene IRF4, potentially exert effects by promoting endogenous DNA damage.
Indexed as
Genome-Wide Association StudyLung NeoplasmsDNA-Binding ProteinsGenetic Predisposition to DiseaseHumansPolymorphism, Single NucleotideQuantitative Trait LociRNA-Binding ProteinsDNA-Binding ProteinsFUBP1 protein, humanRNA-Binding Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.