ArticleNature communications2022
Global analysis and prediction of fluoride in groundwater.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Global groundwater contamination by geogenic fluoride.Environmental geochemistry and health · 2026Pooled it
- Fluoride Exposure and Children's IQ Scores: A Systematic Review and Meta-Analysis.JAMA pediatrics · 2025Pooled it
- Fluoride Exposure and Skeletal Fluorosis: a Systematic Review and Dose-response Meta-analysis.Current environmental health reports · 2023Pooled it
- Lactobacillus johnsonii BS15 Alleviates Fluoride-Induced Intestinal Barrier Injury by Regulating the RhoA/ROCK-Mediated Cytoskeletal Remodeling.Probiotics and antimicrobial proteins · 2026Article
- Biotemplate-assisted synthesis of CaO nanoparticles from banana blossom calyx residue for efficient fluoride removal from water.Water environment research : a research publication of the Water Environment Federation · 2026Article
- Relationships between Toenail, Urinary, and Drinking-water Fluoride Concentrations in a Pregnancy Cohort using Private Water Systems in the United States.Biological trace element research · 2026Article
- Quantification of Fluoride in Serum, Bone, and Teeth in a Murine Model Using Hexamethyldisiloxane-Facilitated Diffusion and Ion-Selective Electrode Measurements.Journal of visualized experiments : JoVE · 2026Article
- From Fluoride Removal to Interfacial Reactivity Enhancement: Functionalized LaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Chronic Fluoride Exposure from Brick Tea Consumption Disrupts Bone Remodeling and Contributes to Bone Loss in Chinese Population with Skeletal Fluorosis.Biological trace element research · 2026Article
- Simultaneous removal of phosphate and fluoride by calcium peroxide in a binary system: performance and mechanisms.RSC advances · 2026Article
- A Tutorial on Best Practices and Pitfalls in Applying Machine Learning to Environmental Research.ACS environmental Au · 2026Article
- Article
- Simultaneous removal of fluoride and arsenic from water in a fixed-bed column using Fe-Al-MOF/CF composite: optimization by response surface methodology.Scientific reports · 2026Article
- Integrated machine learning-bayesian receptor modelling framework for uncertainty-aware source apportionment in a non-stationary fluoride-contaminated coastal aquifer.Scientific reports · 2026Article
- Eggshell-derived hydroxyapatite-alkali-activated waste glass composite for fluoride sequestration: characteristics and mechanistic insights and process optimization.RSC advances · 2026Article
- Diving into AI? Exploring the Potential for AI to Tackle Complex Water Quality Challenges.Environmental science & technology · 2026Review
- Predicting skeletal fluorosis severity using machine learning across diverse fluoride-exposed populations in China.Scientific reports · 2026Article
- Developmental vulnerability to fluoride toxicity: enamel and clearance differences in adolescent versus mature mice.Archives of toxicology · 2026Article
- Article
- Environmental Fluoride Compromises Male Fertility: Differentially Modulated miR-34a-5p Targets REST to Regulate Autophagy in Testicular Somatic Cells.Research (Washington, D.C.) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The health of millions of people worldwide is negatively impacted by chronic exposure to elevated concentrations of geogenic fluoride in groundwater. Due to health effects including dental mottling and skeletal fluorosis, the World Health Organization maintains a maximum guideline of 1.5 mg/L in drinking water. As groundwater quality is not regularly tested in many areas, it is often unknown if the water in a given well or spring contains harmful levels of fluoride. Here we present a state-of-the-art global fluoride hazard map based on machine learning and over 400,000 fluoride measurements (10% of which >1.5 mg/L), which is then used to estimate the human population at risk. Hotspots indicated by the groundwater fluoride hazard map include parts of central Australia, western North America, eastern Brazil and many areas of Africa and Asia. Of the approximately 180 million people potentially affected worldwide, most reside in Asia (51-59% of total) and Africa (37-46% of total), with the latter representing 6.5% of the continent's population. Africa also contains 14 of the top 20 affected countries in terms of population at risk. We also illuminate and discuss the key globally relevant hydrochemical and environmental factors related to fluoride accumulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.