Evidence map›Paper›PMID 35914835›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

Protein Kinase CK2 Controls CD8

Wei Yang, Hairong Wei, Gloria A Benavides, William J Turbitt, Jessica A Buckley, Xiaosen Ouyang, Lianna Zhou, Jianhua Zhang, Laurie E Harrington, Victor M Darley-Usmar and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. CK2B Induces CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  4. Regulation of cancer progression by CK2: an emerging therapeutic target.Medical oncology (Northwood, London, England) · 2024
    Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Wei YangDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL; and.
Hairong WeiDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL; and.
Gloria A BenavidesDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL.
William J TurbittDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL; and.
Jessica A BuckleyDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL; and.
Xiaosen OuyangDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL.
Lianna ZhouDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL; and.
Jianhua ZhangDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0002-7218-1977
Laurie E HarringtonDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL; and.ORCID 0000-0002-6832-9529
Victor M Darley-UsmarDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL.
Hongwei QinDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL; and hqin@uab.edu tika@uab.edu.ORCID 0000-0002-7511-5078
Etty N BenvenisteDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL; and hqin@uab.edu tika@uab.edu.
University of Alabama at Birmingham · US

Funding

Sex hormones and arthritis in a long lived animal modelP30AG050886 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DAVID B ALLISON · 2015 to 2026
$11.3M
Therapeutic Intervention of the JAK/STAT Pathway for NeuroinflammationR01NS057563 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BENVENISTE, ETTY N · 2008 to 2017
$2.7M
The Role of CK2 in Glioblastoma DevelopmentR01CA194414 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BENVENISTE, ETTY N · 2016 to 2020
$1.7M
CD4 T cell stemness and inflammatory bowel diseaseR01DK125870 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HARRINGTON, LAURIE ELLEN · 2020 to 2023
$1.5M
Targeting the JAK/STAT-3 Pathway Signaling Axis in GliomaR01CA158534 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BENVENISTE, ETTY N · 2012 to 2016
$1.5M
Sialylation dependent control of CD8 T cell stemness during chronic viral infectionR21AI142641 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HARRINGTON, LAURIE ELLEN · 2019 to 2020
$408k
NCI NIH HHS R01 CA158534NCI NIH HHS R01 CA194414NIAID NIH HHS R21 AI142641NIA NIH HHS P30 AG050886NIDDK NIH HHS R01 DK125870NINDS NIH HHS R01 NS057563
6 · The paper itself

Abstract

Protein kinase CK2 is a serine/threonine kinase composed of two catalytic subunits (CK2α and/or CK2α') and two regulatory subunits (CK2β). CK2 promotes cancer progression by activating the NF-κB, PI3K/AKT/mTOR, and JAK/STAT pathways, and also is critical for immune cell development and function. The potential involvement of CK2 in CD8

Indexed as

Casein Kinase IINF-kappa BCD8-Positive T-LymphocytesPhosphatidylinositol 3-KinasesProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktReceptors, Antigen, T-CellSerineT-LymphocytesTOR Serine-Threonine KinasesCasein Kinase IINF-kappa BPhosphatidylinositol 3-KinasesProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktReceptors, Antigen, T-CellSerineTOR Serine-Threonine Kinases

Identifiers

PMID35914835
PMCPMC9492634
OpenAlexW4289641136

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.